Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30335

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題名:	Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations
作者:	Chang, JG;Lee, LS;Chen, CM;Shih, MC;Wu, MC;Tsai, FJ;Liang, DC
貢獻者:	附設醫院檢驗醫學部;China Med Coll Hosp, Dept Lab Med, Taichung, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung, Taiwan;Taipei Municipal Jen Ai Hosp, Dept Lab Med, Taipei, Taiwan;Mackay Mem Hosp, Dept Pediat, Haematol Sect, Taipei, Taiwan
日期:	2002
上傳時間:	2010-09-24 14:53:30 (UTC+8)
出版者:	LIPPINCOTT WILLIAMS & WILKINS
摘要:	The purpose of this study was to examine whether interleukin-1beta (IL-1beta) (promoter and exon 5) gene polymorphisms were markers of susceptibility or clinical manifestation in Chinese patients with systemic lupus erythematosus (SLE). The study included 52 Chinese patients with SLE. In addition, 103 unrelated healthy individuals living in central Taiwan served as control subjects. From genomic DNA, polymorphisms of the gene for IL-1beta promoter and exon 5 were typed. Allelic frequencies were compared between SLE patients and control subjects. The relationship between allelic frequencies and clinical manifestations of SLE was evaluated. No significant differences were observed in the allelic frequencies of the IL-1beta promoter and IL-1beta exon 5 between patients with SLE and healthy control subjects. Additionally, we did not detect any association of IL-1beta promoter and the exon 5 genotype with the clinical and laboratory profiles in SLE patients. The results from the present study suggest that the polymorphisms of the IL-1beta promoter and IL-1beta exon 5 are not related to SLE patients in Taiwan.
關聯:	PHARMACOGENETICS 12(3):191-195
顯示於類別:	[台中附設醫院] 期刊論文

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