Blockade of protein kinase C is involved in the inhibition by cycloheterophyllin of neutrophil superoxide anion generation

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Title:	Blockade of protein kinase C is involved in the inhibition by cycloheterophyllin of neutrophil superoxide anion generation
Authors:	Wang, JP;Raung, SL;Tsao, LT;Hsu, MF;Lin, CN
Contributors:	醫學院醫學系生化學科;CHINA MED COLL,DEPT BIOCHEM,TAICHUNG,TAIWAN;KAOHSIUNG MED COLL,SCH PHARM,KAOHSIUNG,TAIWAN
Date:	1997
Issue Date:	2010-09-24 14:53:28 (UTC+8)
Publisher:	SPRINGER VERLAG
Abstract:	Objective: To examine the relationship between ambient lead levels and blood lead levels and to explore the modifiers of the relationship between ambient lead and blood lead, Method: A cross-sectional study was conducted in two lead battery factories. Blood lead level and ambient lead concentration were measured for each participant concurrently. A structured questionnaire was administered to collect sociodemographic characteristics and occupational history, Design: Biological and personal environmental measurements of 219 lead-exposed workers were analyzed by both simple and multiple linear regression, A regression model was selected for interpretation. Results:A high correlation (r = 0.62) between ambient lead (PbA) and blood lead (PbB) was observed. In addition, numerous factors, including age, sex, alcohol consumption, personal hygiene practice and type of lead exposure, were also found to influence blood lead levels, Although PbB was highly correlated with PbA, blood lead level may not be effectively lowered by reducing ambient lead level, Based on the regression coefficients, improvement of hygienic practice was more effective at lowering PbB than reducing ambient lead level. Good hygienic practice may be the preferential way to reduce lead exposure in current conditions, Conclusion: Education of correct work practice may be more important than engineering control in the developing countries to lower blood lead levels in lead battery factories.
Relation:	NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 355(5):551-558
Appears in Collections:	[School of Medicine] Journal articles

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