2',5'-dihydroxychalcone as a potent chemical mediator and cyclooxygenase inhibitor

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學系 > 期刊論文 > Item 310903500/30329

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題名:	2',5'-dihydroxychalcone as a potent chemical mediator and cyclooxygenase inhibitor
作者:	Lin, CN;Lee, TH;Hsu, MF;Wang, JP;Ko, FN;Teng, CM
貢獻者:	醫學院醫學系生化學科;CHINA MED COLL,DEPT BIOCHEM,TAICHUNG 400,TAIWAN;TAICHUNG VET GEN HOSP,DEPT MED RES,TAICHUNG 407,TAIWAN;NATL TAIWAN UNIV,COLL MED,INST PHARMACOL,TAIPEI 100,TAIWAN
日期:	1997
上傳時間:	2010-09-24 14:53:25 (UTC+8)
出版者:	ROYAL PHARMACEUTICAL SOC GREAT BRITAIN
摘要:	Three members of a Taiwanese kindred developed severe, systemic, early onset (< age 25 years), biopsy-proven amyloidosis. Clinical features included upper and lower extremity sensorimotor neuropathy,abdominal pain, vomiting, corneal ulcerations, cardiomyopathy, and syncope. Immunohistochemical analysis indicated that the deposits consisted of transthyretin. Molecular genetic studies revealed a heterozygous codon 55 point mutation, resulting in a proline for leucine substitution, a mutation previously associated with aggressive familial amyloidosis in a US kindred of Dutch and German descent. The clinical courses and echocardiographic findings are typical for many types of amyloidosis; the pathologic data and genetic studies were necessary to establish a precise diagnosis.
關聯:	JOURNAL OF PHARMACY AND PHARMACOLOGY 49(5):530-536
顯示於類別:	[醫學系] 期刊論文

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