Clozapine withdrawal catatonia associated with cholinergic and serotonergic rebound hyperactivity - A case report

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Title:	Clozapine withdrawal catatonia associated with cholinergic and serotonergic rebound hyperactivity - A case report
Authors:	Yeh, AWC;Lee, JWY;Cheng, TC;Wen, JK;Chen, WH
Contributors:	附設醫院精神醫學部;Univ Western Australia, Graylands Hosp, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia;Univ Western Australia, Dept Gen & Adolescent Psychiat, Perth, WA 6009, Australia;China Med Univ Hosp, Dept Psychiat, Taichung, Taiwan;Chang Gung Mem Hosp, Dept Neurol, Kaohsiung, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:53:07 (UTC+8)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Abstract:	Catatonia as a clozapine withdrawal syndrome has not been well documented. There is only 1 case of excited catatonia described with the diagnosis made according to strict criteria. The authors report a patient who developed a catatonic stuporous state following abrupt discontinuation of clozapine, associated with features of cholinergic and serotonergic hyperactivity. The catatonic state resolved within 1 week with reinstatement of clozapine. It is suggested that serotonergic hyperactivity was involved, contributed by cholinergic rebound, in the pathogenesis of this patient's clozapine withdrawal catatonic syndrome.
Relation:	CLINICAL NEUROPHARMACOLOGY 27(5):216-218
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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