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http://ir.cmu.edu.tw/ir/handle/310903500/30310
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| 題名: | A functional polymorphism in the promoter region of the tryptophan hydroxylase gene is associated with alcohol dependence in one aboriginal group in Taiwan |
| 作者: | Sun, HS;Fann, CSJ;Lane, HY;Chang, YT;Chang, CJ;Liu, YL;Cheng, ATA |
| 貢獻者: | 附設醫院精神醫學部;Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan;Natl Cheng Kung Univ, Coll Med, Inst Mol Med, Tainan 70101, Taiwan;China Med Univ Hosp, Dept Psychiat, Taichung, Taiwan;Cathay Gen Hosp, Dept Psychiat, Taipei, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:53:00 (UTC+8) |
| 出版者: | LIPPINCOTT WILLIAMS & WILKINS |
| 摘要: | To investigate the difference of metabolic pharmacokinetics between pure glycyrrhizin (GZ) and GZ in licorice decoction, six New Zealand White rabbits were orally given pure GZ and licorice decoction containing equivalent content of GZ in a randomized crossover design. HPLC methods were used for the quantitation of GZ and glycyrrhetic acid (GA) in serum. The results indicated that the areas under curves (AUCs) of GZ and GA after administration of licorice decoction were significantly higher than those after pure GZ. This result was contradictory with that obtained in rats. To explore the mechanism of the pharmacokinetic difference, feces of rabbits, rats, pigs and humans were used to investigate the presystemic metabolism of pure GZ and GZ in licorice decoction. The results indicated that pure GZ was hydrolyzed to GA more rapidly and to a greater extent than that in licorice decoction by various feces. In addition, when pure GZ was fermented, the metabolic profiles of GA and 3-dehydroGA in rabbit feces were quite different from other feces. In conclusion, the bioavailabilities of GZ and GA are significantly better from licorice than from pure GZ in rabbits but the presystemic metabolism of pure GZ in rabbit is rather different from that in rat, pig and human. (C) 2004 Elsevier Inc. All rights reserved. |
| 關聯: | ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 29(1):1-7 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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