Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia - A randomized, double-blind, placebo-controlled study

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Title:	Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia - A randomized, double-blind, placebo-controlled study
Authors:	Lane, HY;Chang, YC;Liu, YC;Chiu, CC;Tsai, GE
Contributors:	附設醫院精神醫學部;China Med Univ & Hosp, Dept Psychiat, Taichung, Taiwan;Tamkang Univ, Inst Life Sci, Taipei, Taiwan;Tamkang Univ, Dept Math, Taipei, Taiwan;Taipei City Psychiat Ctr, Dept Psychiat, Taipei, Taiwan;Harvard Univ, Sch Med, Belmont, MA 02178 USA;McLean Hosp, Lab Mol & Psychiat Neurosci, Belmont, MA 02178 USA
Date:	2005
Issue Date:	2010-09-24 14:52:43 (UTC+8)
Publisher:	AMER MEDICAL ASSOC
Abstract:	The effects of different dietary ratios of polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) to saturated fatty acids (SFAs) [(PUFA+MUFA)/SFA] on plasma and hepatic lipids, the activities of hepatic regulatory enzymes of cholesterol metabolism, and low-density lipoprotein (LDL) uptake of hepatocytes and Kupffer cells were examined. In this study, 2 different types of diets that had the same PUFA/SFA ratio of 1.0 but each with different (PUFA+MUFA)/SFA ratios of 1.4 (diet 1, control) and 5.7 (diet 2), respectively, were fed to rats. Rats fed with diet 2 showed significantly increased plasma total triacylglycerol (TAG; 21%), very low density lipoprotein (VLDL) TAG (28%), and VLDL cholesterol (113%) levels compared with those fed with diet 1. Plasma LDL cholesterol concentration was not different between the 2 dietary groups of rats. Rats fed with diet 2 also had significantly increased hepatic cholesteryl ester concentrations (155%) and excreted less neutral sterol (35%) compared with rats in the diet I group. The activities of hepatic acyl coenzyme A (CoA): cholesterol acyltransferase and cholesterol 7 alpha-hydroxylase for rats in diet group 2 were significantly increased (38% and 39%, respectively), and hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity decreased (21%) compared with the values in diet group 1. Uptake of LDL by hepatocytes (106%) and Kupffer cells (140%) was higher in rats fed with diet 2 compared with rats fed with diet 1. In summary, the diet with a high ratio (PUFA+MUFA)/SFA increased plasma total TAG, VLDL TAG, and VLDL cholesterol concentrations and liver cholesteryl ester by elevating hepatic acyl CoA:cholesterol acyltransferase and 7 alpha-hydroxylase activities, lowering hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity, and increasing LDL uptake by hepatocytes and Kupffer cells. (c) 2005 Elsevier Inc. All rights reserved.
Relation:	ARCHIVES OF GENERAL PSYCHIATRY 62(11):1196-1204
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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