Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders

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Title:	Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders
Authors:	Lane, HY;Lin, CC;Huang, CH;Chang, YC;Hsu, SK;Chang, WH
Contributors:	附設醫院精神醫學部;China Med Univ Hosp, Dept Psychiat, Taichung 404, Taiwan;China Med Univ Hosp, Dept Med Res, Inst Med Sci, Taichung, Taiwan;Tamkang Univ, Dept Math, Taipei, Taiwan;Tzu Chi Univ, Dept Psychiat, Hualien, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:52:37 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	To determine whether high polyunsaturated and monounsaturated fatty acid to saturated fatty acid [(P+M)/S] ratio in diets increases plasma lipoprotein lipids and reduces the hepatic hypertriglyceridemic effect of dietary cholesterol, we compared plasma lipoproteins and liver lipids in 64 rats. Rats were fed diets with the same polyunsaturated fatty acids/saturated fatty acids (P/S) ratio of 1.0, but different (P+M)/S ratios of 1.5, 2, 4, or 5.7 without (experiment 1) or with 1% cholesterol supplement (experiment 2). We found that the plasma total cholesterol (C), and low density lipoprotein (LDL)-C concentrations were significantly higher in rats fed with the (P+M)/S ratio of 5.7 compared with rats fed with the (P+M)/S ratio of 1.5 or 2.0. As to the very low density lipoprotein (VLDL)-C, rats fed with 5.7 or 4.0 ratio had higher concentration than rats fed with 1.5 or 2.0 ratio. With 1% choesterol supplement, when rats were fed with the ratio of (P+M)/S which increased from 1.5, 2, 4 to 5.7, there was a progressive increase in plasma total cholesterol (P=0.0001), total triacylglycerol (TAG, P=0.0091), total phospholipid (PL, P=0.0006), VLDL-C (P=0.0001), VLDL-TAG (P=0.0119), VLDL-PL (P=0.0013), LDL-C (P=0.0001), LDL-TAG (P=0.0006), and LDL-PL (P=0.0001) concentrations. There was also a progressive increase in liver C level (P=0.005) and decrease in liver TAG level (P=0.004) with 1% C supplement. However, without 1% cholesterol supplement, no such a trend was found for plasma total, lipoproteins, and liver lipids. We conclude that high (P+M)/S ratio increases plasma VLDL and LDL lipids and reduces the hepatic hypertriglyceridemic effect of dietary cholesterol in rats. These results suggest that the higher (P+M)/S ratio is more cholesterolemic and hepatocholesterolemic than lower (P+M)/S ratio in rats fed with high-cholesterol diet. (C) 2004 Elsevier Inc. All rights reserved.
Relation:	SCHIZOPHRENIA RESEARCH 67(1):63-70
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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