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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30287
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| 題名: | Oligomerization of acidic fibroblast growth factor is not a prerequisite for its cell proliferation activity |
| 作者: | Arunkumar, AI;Kumar, TKS;Kathir, KM;Srisailam, S;Wang, HM;Leena, PST;Chi, YH;Chen, HC;Wu, CH;Wu, RT;Chang, GG;Chiu, IM;Yu, C |
| 貢獻者: | 醫學院醫研所;Ohio State Univ, Dept Internal Med, Davis Med Res Ctr, Columbus, OH 43210 USA;Natl Tsing Hua Univ, Dept Chem, Hsinchu, Taiwan;China Med Coll, Inst Med Res, Dept Pharmacol, Taichung, Taiwan;China Med Coll, Dept Pharmacol, Taichung, Taiwan;Natl Yang Ming Univ, Res Ctr Drug Discovery, Grad Inst Biopharmaceut Sci, Taipei, Taiwan;Natl Def Med Ctr, Dept Biochem, Taipei 10764, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 14:52:37 (UTC+8) |
| 出版者: | COLD SPRING HARBOR LAB PRESS |
| 摘要: | Recently, by using differential display on specimens of non-small cell lung cancer (NSCLC), we detected overexpression of dihydrodiol dehydrogenase (DDH) that was rarely expressed in the corresponding normal lung tissue. DDH overexpression was correlated with poor prognosis of patients with advanced NSCLC. Because DDH could metabolize polycyclic aromatic hydrocarbons (PAH) in the liver, DDH overexpression in NSCLC would suggest an association with carcinogenesis and disease progression. In this study, we investigated DDH expression in 103 patients with resected stage I NSCLC. Expression of DDH was detected by using immunohistochemistry. Relation between DDH expression and clinicopathological parameter (age, gender, smoking habit, tumor status, histological type, cell differentiation, local recurrence, distant metastasis or survival) was analyzed by statistical analysis. DDH overexpression was detected in 39 (37.9%) of 103 pathological sections. Frequency of DDH overexpression was significantly higher in male patients (p=0.043) and patients with squamous cell carcinoma (p<0.005). Among 103 patients, 14 patients had local recurrence and 28 patients had distant metastasis during follow-up examination. The 5-year survival rate of these patients was poorer than those who did not have local recurrence or distant metastasis (both were p<0.005, respectively). Although patients with low DDH expression had more favorable outcome than those with DDH overexpression, in terms of survival rate no statistical significance was detected (p=0.889). The results suggest that DDH expression may serve as an early but not prognostic biomarker for patients with resectable stage I NSCLC. |
| 關聯: | PROTEIN SCIENCE 11(5):1050-1061 |
| 顯示於類別: | [醫學研究所] 期刊論文
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