2-Methoxyestradiol Induces Apoptosis and Cell Cycle Arrest in Human Chondrosarcoma Cells.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 中醫學系暨碩博班 > 期刊論文 > Item 310903500/3026

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题名:	2-Methoxyestradiol Induces Apoptosis and Cell Cycle Arrest in Human Chondrosarcoma Cells.
作者:	馮逸卿(Yi-Chin Fong);楊維宏(Wei-Hung Yang);許昇峰(Sheng-Feng Hsu);許弘昌(Horng-Chaung Hsu);(Kuo-Fung Tseng);(Chin-Jung Hsu);(Chun-Yi Lee);(Sean P. Scully)*
贡献者:	中醫學院中醫學系學士班中醫外傷學科;中國附醫骨科部
关键词:	2-methoxyestradiol;chondrosarcoma;anti-tumor effect;apoptosis
日期:	2007-04
上传时间:	2009-08-20 17:58:35 (UTC+8)
摘要:	2-Methoxyestradiol (2ME) is an endogenous metabolite with estrogen receptor-independent anti-tumor activity. The current study seeks to determine the mechanism of anti-tumor activity of 2ME on human chondrosarcoma. 2ME caused a time- and dose-dependent cytotoxity in chondrosarcoma cells, while primary chondrocytes were minimally affected. Cells accumulated in G0/G1 phase in response to 2ME and DAPI stain indicated an induction of apoptosis. Bax, Cytochrome C, and Caspase-3 protein expression were increased, while p53 expression was decreased. A higher Bax/Bcl-2 ratio followed 2ME treatment. 2ME has a potentially promising role as a systemic therapy of chondrosarcoma when the mechanism of action is better delineated.
關聯:	JOURNAL OF ORTHOPAEDIC RESEARCH 25(8):1106~1114
显示于类别:	[中醫學系暨碩博班] 期刊論文

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