The adjustment to illness in patients with generalized anxiety disorder is poorer than that in patients with end-stage renal disease

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Title:	The adjustment to illness in patients with generalized anxiety disorder is poorer than that in patients with end-stage renal disease
Authors:	Yeh, TL;Huang, CL;Yang, YK;Lee, YD;Chen, CC;Chen, PS
Contributors:	附設醫院經神醫學部;Natl Cheng Kung Univ, Coll Med, Dept Psychiat, Tainan 704, Taiwan;Chinese Med Univ Hosp, Dept Psychiat, Taichung, Taiwan;Eli Lilly & Co Taiwan Inc, Taipei, Taiwan;Pfizer Taiwan Pfizer Global Pharmaceut, Taipei, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:51:41 (UTC+8)
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Abstract:	Reactive oxygen metabolites may contribute to the development of end-stage renal disease (ESRD) in diabetic and hypertensive patients. In this study, we used multiplex polymerase chain reaction (PCR) to analyze polymorphisms of two endogenous antioxidant genes, glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1), and to determine their role in the development of ESRD in diabetic and hypertensive patients. Our results showed that homozygous deletion of the GSTT1 gene is a risk factor for developing ESRD in diabetic patients (p=0.004, OR=2.18, 95% confidence interval (CI) =1.29-3.70), but not in hypertensive patients. No association between homozygous deletion of GSTM1 and the development of ESRD was found in either diabetic patients or hypertensive patients. These results indicate that genetic variations in enzymes involved in free radical metabolism are associated with the development of ESRD in diabetes mellitus (DM) patients, and may permit the targeting of preventive and early intervention strategies to high-risk individuals.
Relation:	JOURNAL OF PSYCHOSOMATIC RESEARCH 57(2):165-170
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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