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http://ir.cmu.edu.tw/ir/handle/310903500/30227
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| 題名: | Lower limb wrapping prevents hypotension, but not hypothermia or shivering, after the introduction of epidural anesthesia for cesarean delivery |
| 作者: | Sun, HL;Ling, QD;Sun, WZ;Wu, RSC;Wu, TJ;Wang, SC;Chien, CC |
| 貢獻者: | 附設醫院麻醉部;Cathay Gen Hosp, Dept Anesthesiol, Taipei, Taiwan;Cathay Gen Hosp, Cathay Med Res Inst, Taipei, Taiwan;Natl Taiwan Univ Hosp, Dept Anesthesiol, Taipei, Taiwan;China Med Coll Hosp, Dept Anesthesiol, Pain Serv & Crit Care Med, Taipei, Taiwan |
| 日期: | 2004 |
| 上傳時間: | 2010-09-24 14:51:30 (UTC+8) |
| 出版者: | LIPPINCOTT WILLIAMS & WILKINS |
| 摘要: | Background Scarring and collagen deposition in the valves and destruction of myocytes may result from the combined effects of a smoldering rheumatic process and a constant trauma to the mitral vlave or aortic valve by the turbulent flow in rheumatic heart disease (RHD). Transforming growth factor-beta1 (TGF-beta1) may be responsible for the increased valvular fibrosis and calcification in the pathogenesis of RHD. However, the role of TGF-beta1 genetic variant in RHD has not been studied. This case-controlled study was carried out to investigate the possible relationship between the TGF-beta1 gene C-509T and T869C polymorphisms and RHD among the Chinese population in Taiwan. Methods A group of 115 patients with RHD documented by using echocardiography and 100 age- and sex-matched healthy control patients were studied. TGF-beta1 gene C-509T and T869C polymorphisms were identified with polymerase chain reaction-based restriction analysis. Results A significant difference was seen in the distribution of genotypes between patients with RHD and control patients for either TGF-beta1 C-509T polymorphism (P < .0001) or T869C polymorphism (P < .0001). The frequency of TGF-beta1 C-509T CC genotype was lower in the RHD group than in the control group (chi(2) = 19.05, P < .0001), which suggests that this genotype may confer protective effects against RHD. A significant difference was seen in the distribution of allelic frequency between patients with RHD and control patients for TGF-beta1 T869C polymorphism (P = .04). The odds ratio (OR) for risk of RHD associated with TGF-beta1 T869C T allele was 1.49 (95% CI, 1.02-2.19). Further categorization of patients with RHD into mitral valve disease and combined valve disease subgroups revealed no statistical difference in these gene polymorphisms when compared with the 2 subgroups. Conclusions Patients with RHD have a lower frequency of TGF-beta1 C-509T CC genotype and a higher frequency of T869C T allele, which supports a role for the TGF-beta1 gene C-509T and T869C polymorphisms in determining the risk/ protection of RHD in Taiwan Chinese patients. |
| 關聯: | ANESTHESIA AND ANALGESIA 99(1):241-244 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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