DNA fragmentation, mitochondrial dysfunction and chromosomal aneuploidy in the spermatozoa of oligoasthenoteratozoospermic males

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Title:	DNA fragmentation, mitochondrial dysfunction and chromosomal aneuploidy in the spermatozoa of oligoasthenoteratozoospermic males
Authors:	Liu, CH;Tsao, HM;Cheng, TC;Wu, HM;Huang, CC;Chen, CI;Lin, DPC;Lee, MS
Contributors:	醫學院醫學系;Lee Womens Hosp, Infertil Clin Div, Taichung 406, Taiwan;Chung Shan Med Univ, Inst Med, Taichung, Taiwan;Chung Shan Med Univ, Inst Biochem, Taichung, Taiwan;China Med Coll Sch Med, Taichung, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:51:18 (UTC+8)
Publisher:	KLUWER ACADEMIC/PLENUM PUBL
Abstract:	Cardiac complications caused by iron deposition are major causes of death in patients with beta-thalassemia major. Deferiprone (L1) was found to have greater efficacy at depleting myocardial iron than desferrioxamine (DFX). Furthermore, combined therapy with L1 and DFX produced an additive or synergistic iron chelating effect. We report the successful treatment of severe heart failure in two patients with beta-thalassemia major with the combined therapy. Magnetic resonance images showed a marked recovery of signal intensity in the heart, indicating a significant reduction of iron load in the heart. No significant adverse effects were noted. Therefore, combined therapy with L1 and DFX should be considered in patients with beta-thalassemia major and cardiac complications.
Relation:	JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 21(4):119-126
Appears in Collections:	[School of Medicine] Journal articles

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