Oxidative DNA damage in pterygium

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Title:	Oxidative DNA damage in pterygium
Authors:	Tsai, YY;Cheng, YW;Lee, H;Tsai, FJ;Tseng, SH;Lin, CL;Chang, KC
Contributors:	附設醫院眼科部;China Med Univ Hosp, Dept Ophthalmol, Taichung, Taiwan;China Med Univ Hosp, Dept Med Genet, Taichung, Taiwan;China Med Univ Hosp, Dept Phys Med & Rehabil, Taichung, Taiwan;China Med Univ Hosp, Coll Chinese Med, Taichung, Taiwan;Chung Shan Med Univ, Inst Med, Taichung, Taiwan;Chung Shan Med Univ, Inst Toxicol, Taichung, Taiwan;Natl Cheng Kung Univ Hosp, Dept Ophthalmol, Tainan, Taiwan;Natl Cheng Kung Univ Hosp, Dept Pathol, Tainan, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:51:17 (UTC+8)
Publisher:	MOLECULAR VISION
Abstract:	The purpose of this study was to determine whether low-power pulsed laser irradiation could affect the regeneration of a 10-mm gap of rat sciatic nerve created between the proximal and distal nerve stumps, which were sutured into silicone rubber tubes. After 8 weeks of recovery, pulsed laser-irradiated groups at frequencies of 5 kHz and 20 kHz both had significantly lower success percentages of regeneration (50% and 44%, respectively) compared to sham-irradiated controls (100%). In addition, qualitative and quantitative histology of the regenerated nerves revealed a less mature ultrastructural organization with a smaller cross-sectional area and a lower number of myelinated axons in both pulsed laser-irradiated groups than in controls. These results suggest that pulsed laser irradiation could elicit suppressing effects on regenerating nerves. (C) 2004 Wiley-Liss, Inc.
Relation:	MOLECULAR VISION 11(8月9日):71-75
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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