Spontaneous regression of dense epithelial ingrowth after laser in situ keratomileusis

CMUR > China Medical University Hospital > Jurnal articles > Item 310903500/30187

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Title:	Spontaneous regression of dense epithelial ingrowth after laser in situ keratomileusis
Authors:	Lin, JM;Tsai, YY;Tseng, SH
Contributors:	附設醫院眼科部;China Med Univ Hosp, Dept Ophthalmol, Taichung 404, Taiwan;Chung Shan Med Univ, Inst Med, Taichung, Taiwan;Natl Cheng Kung Univ Hosp, Dept Ophthalmol, Tainan 70428, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:50:47 (UTC+8)
Publisher:	SLACK INC
Abstract:	Cordyceps (Cordyceps sinensis SACCARDO.) is a popular traditional tonic used in Taiwan and mainland China. Cyclosporin is an important immunosuppressant with narrow therapeutic index. This study investigated the effect of coadministration of cordyceps on cyclosporin pharmacokinetics in rats. Cyclosporin was intravenously (0.8 mg/kg) and orally (2.5 mg/kg) administered with and without cordyceps (2.0 g/kg), respectively, in crossover designs. Blood samples were collected by cardiopuncture and quantitated by a specific monoclonal fluorescence polarization immunoassay. Pharmacokinetic parameters of cyclosporin were calculated using noncompartment model. Paired Student's t-test was used for statistical comparison. Our results indicated that oral coadministration of cordyceps significantly decreased the C-max and AUC(0-540) of cyclosporin by 85.5% and 83.2%, respectively. In addition, when rats were given cordyceps 1 hr before cyclosporin dosing, the C-max and AUC(0-540) of cyclosporin were significantly decreased by 85.9% and 84.4%, respectively. By contrast, when cyclosporin was given as an intravenous bolus, the disposition of cyclosporin was not altered by cordyceps, indicating that the interaction between oral cyclosporin and cordyceps occurred during the absorption phase. In conclusion, cordyceps markedly decreased the oral bioavailability of cyclosporin. Patients treated with cyclosporin are suggested to avoid the concurrent use of cordyceps for efficacy and safety.
Relation:	JOURNAL OF REFRACTIVE SURGERY 21(3):300-302
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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