Development and comparison of automated classifiers for glaucoma diagnosis using stratus optical coherence tomography

CMUR > China Medical University Hospital > Jurnal articles > Item 310903500/30185

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Title:	Development and comparison of automated classifiers for glaucoma diagnosis using stratus optical coherence tomography
Authors:	Huang, ML;Chen, HY
Contributors:	附設醫院眼科部;China Med Univ Hosp, Dept Ophthalmol, Glaucoma Serv, Taichung 404, Taiwan;Natl Chin Yi Inst Technol, Dept Ind Engn & Management, Taichung, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:50:46 (UTC+8)
Publisher:	ASSOC RESEARCH VISION OPHTHALMOLOGY INC
Abstract:	In the present study, experiments were performed to explore the action of quercetin, the most widely distributed flavonoids, and its major metabolite, quercetin-3'-sulfate, on lipopolysaccharide (LPS)- and interferon-gamma (IFN-gamma)-induced nitric oxide (NO) production in BV-2 microglia. Quercetin could suppress LPS- and IFN-gamma-induced NO production and inducible nitric oxide synthase (iNOS) gene transcription, while quercetin-3'-sulfate had no effect. LPS-induced I kappa B kinase (IKK), nuclear factor-kappa B (NF-kappa B) and activating protein-1 (AP-1) activation, and IFN-gamma-induced NF-kappa B, signal transducer and activator of transcription-1 (STAT1) and interferon regulatory factor-1 (IRF-1) activation were reduced by quercetin. Moreover quercetin was able to induce heme oxygenase-1 expression. To address the involvement of heme oxygenase-1 induction in iNOS inhibition, heme oxygenase-1 antisense oligodeoxyrtucleotide was used. Quercetin-mediated inhibition of NO production and iNOS protein expression were partially reversed by heme oxygenase-1 antisense oligodeoxynucleotide, but was mimicked by hemin, a heme oxygenase-1 inducer. The involvement of signal pathways in quercetin-induced heme oxygenase-1 gene expression was associated with tyrosine kinase and mitogen-activated protein kinases activation. All these results suggest quercetin should provide therapeutic benefits for suppression of inflammatory-related neuronal injury in neurodegenerative diseases. (c) 2005 Elsevier B.V. All rights reserved.
Relation:	INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 46(11):4121-4129
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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