RETINAL NERVE FIBER LAYER THICKNESS MEASURED BY OPTICAL COHERENCE TOMOGRAPHY AND ITS CORRELATION WITH VISUAL FIELD DEFECTS IN EARLY GLAUCOMA

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题名:	RETINAL NERVE FIBER LAYER THICKNESS MEASURED BY OPTICAL COHERENCE TOMOGRAPHY AND ITS CORRELATION WITH VISUAL FIELD DEFECTS IN EARLY GLAUCOMA
作者:	Chen, HY;Wang, TH;Lee, YM;Hung, TJ
贡献者:	附設醫院眼科部;[Chen, Hsin-Yi;Lee, Yiu-Mei;Hung, Tsui-Jan] China Med Univ Hosp, Dept Ophthalmol, Taichung 404, Taiwan;[Wang, Tsing-Hong] Natl Taiwan Univ Hosp, Dept Ophthalmol, Taipei, Taiwan
日期:	2005
上传时间:	2010-09-24 14:50:40 (UTC+8)
出版者:	ELSEVIER SINGAPORE PTE LTD
摘要:	Study objectives: Interleukin-10 (IL-10) is mainly an anti -inflammatory cytokine produced by a number of cells including normal and neoplastic cells and has been implicated in autoimmunity, transplantation tolerance and tumorigenesis. Interindividual variations in IL-10 production were genetically contributed to polymorphisms within IL-10 promoter region. The aim of this study was to determine whether polymorphisms in the IL-10 gene promoter were involved in predisposing an individual to non-small cell lung cancer (NSCLC). Patients: A total of 154 patients with non-small cell lung cancer were recruited into this study, together with 205 age- and gender-matched healthy smokers acting as control subjects. Measurements: Polymorphisms of sites within the promoter region of IL-10 gene were analyzed using polymerase chain reaction-restriction fragment length potymorphism technique on genomic DNA isolated from peripheral lymphocytes. The validity of thin technique was proven by direct sequencing of polymerase chain reaction products. Statistical analyses were conducted to explore the contribution of polymorphism of IL-10 promoter to the susceptibility to NSCLC. Results: The distribution frequencies of genotypes of IL-10-1082, -819 and -592 were significantly different between NSCLC patients and controls. Pearson chi(2) analysis showed that the frequency for IL-10-1082 G allete, IL-10-819C allele and IL-10-592C allele was independently higher in NSCLC patient group than that in the control group. Higher odds ratios (ORs) for NSCLC were seen for individuals with G allete of IL-10-1082 [OR=5.26, 95% CI 2.65-10.4, p < 0.0001], C allele of IL-10-819 [OR= 1.57, 95% CI 1.15-2.16, p=0.005], C allete of IL-10-592 [OR= 1.59, 95% CI 1.15-2.19, p=0.005]. Conclusion: The polymorphisms of IL-10 genes were significantly associated with the occurrence of NSCLC. (c) 2005 Elsevier Ireland Ltd. Alt rights reserved.
關聯:	JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 104(12):927-934
显示于类别:	[台中附設醫院] 期刊論文

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