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http://ir.cmu.edu.tw/ir/handle/310903500/30178
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| 題名: | Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing |
| 作者: | Wen, CY;Ito, M;Chen, LD;Matsuu, M;Shichijo, K;Nakayama, T;Nakashima, M;Xu, ZM;Ohtsuru, A;Hsu, CT;Sekine, I |
| 貢獻者: | 醫學院醫學系;Nagasaki Univ, Sch Med, Dept Mol Pathol, Atom Bomb Dis Inst, Nagasaki 8528523, Japan;Nanjing Univ, Sch Med, Nanjing Drum Tower Hosp, Dept Digest Dis, Nanjing 210008, Peoples R China;Natl Nagasaki Med Ctr, Dept Pathol, Omura, Japan;Nagasaki Univ, Sch Med, Atom Bomb Dis Inst, Div Sci Data Registry,Tissue & Hepatopathol Sect, Nagasaki 8528523, Japan;Nagasaki Univ, Sch Med, Atom Bomb Dis Inst, Dept Nat Med, Nagasaki 8528523, Japan;China Med Coll, Sch Med, Dept Pathol, Taichung, Taiwan |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 14:50:39 (UTC+8) |
| 出版者: | SPRINGER-VERLAG TOKYO |
| 摘要: | Background: The effects of paclitaxel on the in vivo distribution and the levels of N-acetylation of 2-aminofluorene (AF) and AF-DNA adducts in Sprague-Dawley (SD) rats were studied. Methods and Results: For in vivo examination, pretreatment with paclitaxel (50 mg/kg) 48 hours prior to the administration of AF (50 mg/kg) resulted in a 28% and 43% decrease, respectively, in the urinary and fecal recovery of N-acetyl-2-aminofluorene (AAF), and a 22% decrease in the metabolic clearance of AF to AAF. Paclitaxel did not affect the Michaelis-Menten parameters for N-acetyltransferase (NAT) activity in blood, liver, lung, colon and bladder. Similarly, the Kin value for AF in the examined tissues was not affected by paclitaxel. However, the Vmax value estimate of liver NAT activity was significantly decreased after paclitaxel pretreatment. Following exposure of rats to AF with and without pretreatment with pactitaxel DNA-AF adducts were examined in the target tissues', liver. colon and bladder, and also in non-target tissues, lung and circulating leukocytes. The DNA-AF adducts in the liver, bladder. lung, colon and leukocytes were decreased by pretreatment with paclitaxel. Conclusion: This is the first finding to show that paclitaxel affects AF distribution and N-acetylation and DATA adduct in SD rats in vivo. |
| 關聯: | JOURNAL OF GASTROENTEROLOGY 38(5):431-435 |
| 顯示於類別: | [醫學系] 期刊論文
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