Locally advanced nasopharyngeal cancer: Long-term outcomes of radiation therapy

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Title:	Locally advanced nasopharyngeal cancer: Long-term outcomes of radiation therapy
Authors:	Lin, JC;Jan, JS
Contributors:	醫學院醫學系;Taichung Vet Gen Hosp, Dept Radiat Oncol, Taichung 40705, Taiwan;Natl Yang Ming Univ, Inst Clin Med, Coll Med, Taipei 112, Taiwan;China Med Coll, Sch Med, Taichung, Taiwan
Date:	1999
Issue Date:	2010-09-24 14:49:26 (UTC+8)
Publisher:	RADIOLOGICAL SOC NORTH AMER
Abstract:	The 10q23.3 gene PTEN (phosphatase and Tensin homologue deleted on chromosome 10) or MMAC1 (mutated in multiple advanced cancers 1) was recently reported to undergo frequent mutation, including mutations and deletions in multiple advanced cancers. This study showed that the aberrant transcripts of this gene are frequently found in cancers of the digestive tract, paired non-cancerous tissues and normal peripheral mononuclear cells. Sequence analysis of the aberrant transcripts revealed three types of deletions: (i) a deletion junction with a splicing-like donor or acceptor sequence; (ii) several-base homology near or between the donor acceptor site at the deletion junction; and (iii) deletion with insertion. From these results, it is suggested that aberrant transcripts of PTEN/MMAC1 found by nested reverse transcription-polymerase chain reaction are a common (or natural) phenomenon unrelated to oncogenesis. The mechanism producing these aberrant transcripts needs further investigation. Using single-strand conformation polymorphism and direct sequencing to analyse for small base changes of the genomic DNA of the PTEN/MMAC1 gene revealed no point mutations or small base changes. (C) 1999 Elsevier Science Ltd. All rights reserved.
Relation:	RADIOLOGY 211(2):513-518
Appears in Collections:	[School of Medicine] Journal articles

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