Classical cadherin and catenin expression in normal myometrial tissues and uterine leiomyomas

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Title:	Classical cadherin and catenin expression in normal myometrial tissues and uterine leiomyomas
Authors:	Tai, CT;Lin, WC;Chang, WC;Chiu, TH;Chen, GTC
Contributors:	附設醫院婦產部;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:49:24 (UTC+8)
Publisher:	WILEY-LISS
Abstract:	Background Some studies have reported that patients with mitral valve prolapse syndrome (MVPS) also have a disorder in the autonomic or neuroendocrine function, which can cause a host of related symptoms. A potential role of the renin-angiotensin system in the pathogenesis of MVPS has been addressed. However, the role of angiotensin 1-converting enzyme (ACE) genetic variant in MVPS has not been studied. We therefore performed a case-control study investigating the possible relation between ACE gene polymorphisms and MVPS in Taiwan Chinese. Methods We studied 100 patients with MVPS diagnosed by echocardiography and 100 age- and sex-matched normal control patients. ACE gene insertion/deletion (I/D), A-240T, and G2350A polymorphisms were identified by polymerase chain reaction-based restriction analysis. Results There was a significant difference in the distribution of ACE I/D genotypes (P = .003) and allelic frequencies, (P = .001) between MVPS cases and control patients. An odds ratio for the risk of MVPS associated with the ACE II genotype was 2.14 (95% Cl 1.20-3.80). An odds ratio for the risk of MVPS associated with ACE I allele was 1.96 (95% Cl 1.30-2.97). The A-240T and G2350A polymorphisms of the ACE gene showed no association with MVPS (P = .20, P = .13, respectively). Conclusions This study showed that patients with MVPS have a higher. frequency of ACE II genotype, which supports a role of the ACE I/D gene polymorphism in determining the risk of MVPS among the Chinese population in Taiwan.
Relation:	MOLECULAR REPRODUCTION AND DEVELOPMENT 64(2):172-178
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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