Use of autologous buccal mucosa for vaginoplasty: a study of eight cases

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30104

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题名:	Use of autologous buccal mucosa for vaginoplasty: a study of eight cases
作者:	Lin, WC;Chang, CYY;Shen, YY;Tsai, HD
贡献者:	附設醫院婦產部;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung 404, Taiwan
日期:	2003
上传时间:	2010-09-24 14:49:19 (UTC+8)
出版者:	OXFORD UNIV PRESS
摘要:	Objective: To investigate the correlation of the androgen receptor gene microsatellite polymorphism (CAG trinucleotide repeat polymorphism on exon 1) with bone mineral density and their relationship to osteoporosis in postmenopausal women. Study design: A number of 168 of 477 postmenopausal women were randomly recruited. The androgen receptor gene microsatellite polymorphism was determined using polymerase chain reaction-based microsatellite analysis. Bone mineral density of the lumbar spine and proximal femur was measured using dual-energy X-ray absorptiometry. Results: The AR genotype was classified from "9" to "32" according to the number of CAG trinucleotide repeats they contained to represent "signposts". After adjustment for potential confounding factors such as age, height, weight, years since menopause, and daily calcium intake, subjects with genotype 20+ (n = 64) had lower bone mineral density values and a significantly greater risk for osteoporosis (OR 4.2, 95% CI 1.0-17.2) when compared with subjects with genotype 20- (n = 104) at the femoral neck. Conclusion: The present study suggests that the androgen receptor gene microsatellite polymorphism may be a candidate genetic marker for risk of osteoporosis in postmenopausal women. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
關聯:	HUMAN REPRODUCTION 18(3):604-607
显示于类别:	[台中附設醫院] 期刊論文

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