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| 題名: | The effect of physician experience on costs and clinical outcomes of laparoscopic-assisted vaginal hysterectomy: A multivariate analysis |
| 作者: | Chang, WC;Li, TC;Lin, CC |
| 貢獻者: | 附設醫院婦產部;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung 404, Taiwan;China Med Coll Hosp, Inst Hlth Care Management, Taichung 404, Taiwan;China Med Coll Hosp, Inst Chinese Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Publ Hlth, Taichung 404, Taiwan |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 14:49:03 (UTC+8) |
| 出版者: | JOURNAL AMER ASSOC GYNECOLOGIC LAPAROSCOPISTS |
| 摘要: | Insufficient angiogenesis and microcirculatory intravascular clotting have been implicated in the pathophysiology of skin flap failure. Salvianolic acid B (Sal B), isolated from Salvia miltiorrhiza, has been reported to enhance angiogenesis in vitro. This study was aimed to determine the efficacy of Sal B on ischemia-reperfusion injury of the skin flap in Sprague-Dawley rats. Sal B was administered intraperitoneally 2 h before operation, and on the 2nd and 4th days after surgical elevation of an extended epigastric adipocutaneous flap (5 x 7 cm) in ketamine anesthetized rats. Flap ischemia was achieved by ligating the right superficial epigastric artery and vein and clamping the left superficial epigastric artery and vein for 3 h and then released. Percentage of flap necrosis area (FNA) and plasma levels of aspartate aminotransferase, alanine aminotransferase, creatinine and malondialdehyde were measured at 7 days after the operation. Animals were divided into six groups, including: vehicle, Sal B low dose (5 mg/kg), Sal B high dose (50 mg/kg) and each with [mesh(+)] or without mesh [mesh(-)] placement. In the three groups with mesh(+), FNA in control flaps was 53.7 +/- 6.9%, whereas low-dose and high-dose Sal B significantly improved flap survival with FNA 27.4 +/- 3.8% and 25.3 +/- 4.3%, respectively (P < 0.05, one-way ANOVA). In the three groups with mesh(-), control flaps were 35.9 +/- 4.5%, whereas high-dose Sal B also significantly improved flap survival with FNA 17.9 +/- 4.7% (P < 0.05, one-way ANOVA). There were no differences in aspartate aminotransferase, alanine aminotransferase, creatinine, or malondialdehyde between groups. We conclude that Sal B attenuates ischemia-reperfusion injury of skin flap, and provides therapeutic potential in reconstructive plastic surgery. (C) 2003 Elsevier Inc. All rights reserved. |
| 關聯: | JOURNAL OF THE AMERICAN ASSOCIATION OF GYNECOLOGIC LAPAROSCOPISTS 10(3):356-359 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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