The characteristics of arylamine N-acetyltransferase in Pseudomonas aeruginosa

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Title:	The characteristics of arylamine N-acetyltransferase in Pseudomonas aeruginosa
Authors:	Hsieh, SE;Lo, HH;Chung, JG
Contributors:	醫學院醫學系;Chungtai Jr Coll, Dept Med Technol, Taichung 40605, Taiwan;China Med Coll, Dept Med, Taichung, Taiwan
Date:	1998
Issue Date:	2010-09-24 14:48:59 (UTC+8)
Publisher:	SPRINGER VERLAG
Abstract:	Experiments were carried out to determine the effects of altering the serotonin (5-HT) levels in the hypothalamus on thermoregulatory function in unanesthetized restrained rats. Local perfusion of the hypothalamus with dialysis solution containing 5-hydroxytryptophan (a 5-HT precursor), fluoxetine (a 5-HT reuptake inhibitor), or high potassium significantly increased both colonic temperature (T-co) and the extracellular concentrations of 5-HT in the hypothalamus. Reciprocally, both extracellular concentration of 5-HT in the hypothalamus and T-co were decreased with a dialysis solution containing tetrodotoxin (which blocks the voltage-dependent sodium channel), zero calcium concentration, or systemic administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 5-HT1A agonist). Intrahypothalamic administration of 8-OH-DPAT and (2,5-dimethoxy-4-iodophenyl)-2-aminopropane (a 5-HT2 agonist) produced hypothermic and hyperthermic effects, respectively. The results indicate that elevating the 5-HT levels in the hypothalamus activates postsynaptic 5-HT2 receptors and results in hyperthermic effects, whereas stimulation of presynaptic 5-HT1A receptors in the hypothalamus reduces the endogenous 5-HT release and results in hypothermic effects.
Relation:	CURRENT MICROBIOLOGY 36(6):353-360
Appears in Collections:	[School of Medicine] Journal articles

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