Inhibitory actions of glycyrrhizic acid on arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients

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題名:	Inhibitory actions of glycyrrhizic acid on arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients
作者:	Chung, JG
貢獻者:	醫學院醫學系;China Med Coll, Dept Med, Taichung 400, Taiwan
日期:	1998
上傳時間:	2010-09-24 14:48:46 (UTC+8)
出版者:	MARCEL DEKKER INC
摘要:	Arylamine N-acetyltransferase (NAT) activity in Helicobacter pylori was inhibited by ellagic acid, a possible chemopreventive drug. The NAT activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. Inhibition of growth studies using H. pylori demonstrated that ellagic acid elicited a dose-dependent bactericidal effect in H. pylori cultures, i.e. the greater the concentration of ellagic acid, the greater the inhibition of growth of H. pylori. The IC50 value was 1 mM for inhibition of growth of H. pylori. Cytosols or suspensions of H. pylori with and without selected concentrations of ellagic acid co-treatment showed different percentages of 2-aminofluorene and p-aminobenzoic acid acetylation. The data indicated that there was decreased NAT activity associated with increased ellagic acid in H. pylori cytosols and intact cells. For the cytosol and intact bacteria examinations, the apparent values of K-m and V-max decreased after co-treatment with 1 mM ellagic acid. This report is the first demonstration of ellagic acid inhibition of arylamine NAT activity and ellagic acid inhibition of growth in the bacterium H. pylori.
關聯:	DRUG AND CHEMICAL TOXICOLOGY 21(3):355-370
顯示於類別:	[醫學系] 期刊論文

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