Physician experience affects costs and clinical outcomes in laparoscopy-assisted vaginal hysterectomy

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30069

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题名:	Physician experience affects costs and clinical outcomes in laparoscopy-assisted vaginal hysterectomy
作者:	Chang, WC;Tsai, WC;Lin, CC
贡献者:	附設醫院婦產部;China Med Coll Hosp, Dept OBS GYN, Taichung, Taiwan;China Med Coll, Inst Hlth Care Management, Taichung, Taiwan
日期:	2002
上传时间:	2010-09-24 14:48:40 (UTC+8)
出版者:	ELSEVIER SCI IRELAND LTD
摘要:	Phenylacetate (PA) and related aromatic fatty acids induce antiproliferation and differentiation of cancer cell; they have potent anti-tumor properties with relatively low toxicity. To search for more potent analogues of PA, PA derivatives have been synthesized. In this study, we investigated the effects of six synthetic PA derivatives on the growth of human lung cancer cells. Results showed that the anti-proliferative effects of these synthetic compounds were strong than those of PA, 4-fluoro-N-butylphenylacetamide (H6) is the most potent compound. 4,6-Diamidino-2-phenylindole (DAPI) staining, in situ TUNEL assay and DNA gel electrophoresis analysis indicated that a marked reduction in the number of CH27 cells with H6 was related to the induction of apoptosis. The apoptosis triggered by H6 was accompanied by up-regulation of Bcl-X-S, accumulation of cytosolic cytochrome c and activation of caspase cascade (caspase-9 and -3). Furthermore, H6 induces proteolytic cleavage of poly (ADP-ribose) polymerase, which followed the appearance of caspase activity and preceded DNA fragmentation. Pretreatment with caspase inhibitors markedly inhibited H6-induced caspase activity and apoptosis. These results suggest that H6 may induce apoptosis through a Bcl-X-S and caspase-dependent mechanism. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
關聯:	INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 79(1):39-41
显示于类别:	[台中附設醫院] 期刊論文

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