Expression of TGF-beta isoforms and their receptors during mineralized nodule formation by rat periodontal ligament cells in vitro

CMUR > College of Dentistry > Scoll of Dentistry and Graduate Institute of Dental Sciences > Journal articles > Item 310903500/30026

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/30026

Title:	Expression of TGF-beta isoforms and their receptors during mineralized nodule formation by rat periodontal ligament cells in vitro
Authors:	Chien, HH;Lin, WL;Cho, MI
Contributors:	醫學院牙醫系;SUNY Buffalo, Sch Dent Med, Dept Oral Biol, Buffalo, NY 14214 USA;China Med Coll, Sch Dent, Taichung, Taiwan
Date:	1999
Issue Date:	2010-09-24 14:47:56 (UTC+8)
Publisher:	MUNKSGAARD INT PUBL LTD
Abstract:	The effect of gypenoside, an active component of the Chinese herb Gynostemma pentaphyllum (Thumb) Makino, on human hepatoma cell lines (Hep3B and HA22T) was investigated. Results demonstrated that gypenoside inhibited the proliferation or viability of the Hep3B and HA22T cells in a dose-dependent manner. The Hep3B and HA22T cells treated with gypenoside for 2 days were less DNA stainable and formed a sub-G, peak. The treated cells increased cell numbers in the Ao region as well as shifting the ordinary S phase to the final S phase (D-1 region), and induced a ladder pattern of fragmented DNA of about 200 base pairs. These data suggest that the cell death of the hepatoma cell lines Hep3B and HA22T induced by gypenoside was via apoptosis, and this was confirmed by morphological studies.
Relation:	JOURNAL OF PERIODONTAL RESEARCH 34(6):301-309
Appears in Collections:	[Scoll of Dentistry and Graduate Institute of Dental Sciences] Journal articles

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