Low-dose aspirin for infertile women with thin endometrium receiving intrauterine insemination: A prospective, randomized study

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Title:	Low-dose aspirin for infertile women with thin endometrium receiving intrauterine insemination: A prospective, randomized study
Authors:	Hsieh, YY;Tsai, HD;Chang, CC;Lo, HY;Chen, CL
Contributors:	附設醫院婦產部;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung, Taiwan
Date:	2000
Issue Date:	2010-09-24 14:47:41 (UTC+8)
Publisher:	KLUWER ACADEMIC/PLENUM PUBL
Abstract:	The human liver tumour cell line (J5) was selected in order to evaluate whether or not luteolin affected arylamine N-acetyltransferase (NAT) activity. Using high performance liquid chromatography, the NAT activity for acetylation of arylamine substrates (2-aminofluorene and p-aminobenzoic acid) was determined. The cytosolic NAT activity in human liver tumour cells was 2.74 +/- 0.26 and 1.68 +/- 0.20 nmol/min/mg of protein for 2-aminofluorene and p-aminobenzoic acid, respectively. Luteolin displayed a dose-dependent inhibition to cytosolic NAT activity and intact human liver tumour cells. Time-course experiments showed that NAT activity measured from intact human liver tumour cells was inhibited by luteolin for up to 24 h. Using standard steady-state kinetic analysis, it was shown that luteolin was a possible noncompetitive inhibitor to NAT activity in cytosols. This report is the first to show how luteolin affects NAT activity in human liver tumour cells.
Relation:	JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 17(3):174-177
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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