Recombinant human leukemia inhibitory factor enhances the development of preimplantation mouse embryo in vitro

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题名:	Recombinant human leukemia inhibitory factor enhances the development of preimplantation mouse embryo in vitro
作者:	Tsai, HD;Chang, CC;Hsieh, YY;Lo, HY;Hsu, LW;Chang, SC
贡献者:	附設醫院婦產部;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung, Taiwan;China Med Coll, Dept Med Res, Taichung, Taiwan
日期:	1999
上传时间:	2010-09-24 14:47:20 (UTC+8)
出版者:	ELSEVIER SCIENCE INC
摘要:	A variety of studies suggest that tumour suppressor loci on chromosome 11p are important in various forms of human neoplasia. Recently, a gene located at the chromosome 11p 15.1-15.2 region called TSG101 was discovered and proposed as a candidate tumour suppressor gene in breast cancers. We evaluated the TSG101 gene in a panel of liver cancer cell lines and paired tumours and non-malignant tissues. In this study, four of the seven (57%) cell Lines, eight of the 18 (44%) tumours and four of the 18 (22%) non-malignant liver tissues exhibited aberrant TSG101 transcripts by nested reverse transcription-polymerase chain reaction (RT-PCR) analysis. However, a normal-sized transcript without sequence abnormalities verified by single-stranded conformation polymorphism (SSCP) analysis was expressed at robust levels in all the cell lines and most of the tissue samples tested. In addition, Southern blot analysis could identify no genomic abnormalities of the gene. Our results suggest either that the TSG101 gene may not be involved in hepatocarcinogenesis or that it plays a role in the development and/or progress of hepatocellular carcinomas through an unusual mechanism. (C) 1999 Elsevier Science Ltd. All rights reserved.
關聯:	FERTILITY AND STERILITY 71(4):722-725
显示于类别:	[台中附設醫院] 期刊論文

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