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http://ir.cmu.edu.tw/ir/handle/310903500/29953
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| 題名: | Distribution of oxidation enzyme eNOS and myeloperoxidase in primary open angle glaucoma |
| 作者: | Lin, HJ;Tsai, CH;Tsai, FJ;Chen, WC;Tsai, SW;Fan, SS |
| 貢獻者: | 附設醫院基因醫學部;China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan;China Med Univ Hosp, Dept Ophthalmol, Taichung 404, Taiwan;Taichung Hlth & Management Univ, Taichung, Taiwan;China Med Univ Hosp, Dept Life Sci, Taichung 404, Taiwan;China Med Univ Hosp, Dept Occupat Safety & Hlth, Taichung 404, Taiwan;China Med Univ Hosp, Inst Environm Med, Taichung 404, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:46:26 (UTC+8) |
| 出版者: | WILEY-LISS |
| 摘要: | The effects of ellagic acid on the in vivo N-acetylation and metabolism of 2-aminofluorene (2-AF) were investigated in bladder, blood, colon, kidney, liver, feces and urine samples from male Sprague-Dawley rats. Major metabolites such as 1-OH-2-AAF, 8-OH-2-AAF and 9-OH-2-AAF were found in bladder tissues, 1-OH-2-AAF, 5-OH-2-AAF and 8-OH-2-AAF were found in blood samples, 1-OH2-AAF, 3-OH-2-AAF, 5-OH-2-AAF, 8-OH-2-AAF and 9-OH2-AAF were found in colon tissues, 1-OH-2-AAF, 3-OH-2AAF and 9-OH-2-AAF were found in kidney tissues, 1-OH-2AAF, 3-OH-2-AAF and 8-OH-2-AAF were found in liver tissues, 1-OH-2-AAF, 3-OH-2-AAF, 5-OH-2-AAF and 8-OH2-AAF were found in feces samples and 1-OH-2-AAF, 3-OH2-AAF, 5-OH-2-AAF and 8-OH-2-AAF were also found in urine samples after rats had been orally treated with 2-AF (50 mg/kg) for 24 h. Pretreatment of male rats with ellagic acid (10 mg/kg) 24 h prior to the administration of 2-AF (50 mg/kg) resulted in absence of 8-OH-2-AAF in bladder tissues, and there were significant decreases of 8-OH-2-AAF in blood and urine samples. In blood samples, amounts of 2-AAF and 8-OH-2-AAF were significantly decreased; in colon tissues, amounts of 2-AF, 1-OH-2-AAF and 3-OH-2-AAF, in liver tissues, amounts of 2-AAF, 1-OH-2-AAF and 3-OH-2-AAF,and in urine samples, amounts of 2-AF and 8-OH-2-AAF were significantly decreased in 24-h ellagic acid (EA)-treated rats before 2-AF was added to the diet. However, significantly increased 1-OH-2-AAF concentrations were found in urine samples in 24-h EA-treated rats before 2-AF was administered. In the EA and 2-AF rats, in the same time treated groups, bladder, colon and liver tissues, and feces and urine samples showed significant differences when compared to the ones without EA co-treatment. We saw significant decreases of the amounts of 2-AF and 1-OH-2-AAF in colon tissues. The feces samples showed increased amounts of 2-AAF in EA- and in 2-AF- treated rats in the same time groups, but urine samples showed a decreased amount of 8-OH-2-AAF in both EA-treated groups. The total amounts of 2-AF metabolites in bladder, blood, kidney and liver tissues showed significant difference between control and the group which was EA-treated 24 h before 2-AF was added. The total amounts of 2-AF metabolites in the liver, feces and urine showed significant decreases between control and EA-treated at the same time with 2-AF groups. This is the first report of EA affecting the N-acetylation and metabolism of 2-AF in rat tissues in vivo. |
| 關聯: | JOURNAL OF CLINICAL LABORATORY ANALYSIS 19(2):87-92 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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