Evaluation of TNF-alpha and IL-1 beta polymorphisms in Taiwan Chinese patients with pterygium

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Title:	Evaluation of TNF-alpha and IL-1 beta polymorphisms in Taiwan Chinese patients with pterygium
Authors:	Tsai, YY;Lee, H;Tseng, SH;Cheng, YW;Tsai, CH;Hsu, CM;Tsai, FJ
Contributors:	附設醫院基因醫學部;China Med Univ, Dept Med Genet, Taichung, Taiwan;China Med Univ Hosp, Dept Ophthalmol, Taichung, Taiwan;Chung Shan Med Univ, Inst Med, Taichung, Taiwan;Chung Shan Med Univ, Inst Toxicol, Taichung, Taiwan;Natl Cheng Kung Univ Hosp, Dept Ophthalmol, Tainan 70428, Taiwan;Taichung Healthcare & Management Univ, Taichung, Taiwan;China Med Univ, Coll Chinese Med, Taichung, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:46:24 (UTC+8)
Publisher:	NATURE PUBLISHING GROUP
Abstract:	Purpose: To investigate the biological correlation between vascular endothelial growth factor (VEGF)-C expression and invasive phenotype in ovarian carcinomas. Experimental Design: Gene and protein expression levels of VEGF-C in 10 ovarian carcinoma cell lines were correlated with invasive activity of the cells. The correlation between immunohistochemical expression of VEGF-C and tumor aggressiveness in 73 ovarian carcinomas was also examined with respect to clinicopathologic features and patient outcome. Results: VEGF-C gene and protein expression differed remarkably among the cell lines, and there was a statistical correlation among VEGF-C expression, in vitro invasive activity, and matrix metalloproteinase-2 (MMP-2) gene expression and its activity. Anti-VEGF-C and anti-MMP-2 antibodies inhibited the invasive activity of tumor cells. VEGF-C expression in clinical tissue samples was well correlated with clinical stages, retroperitoneal lymph node metastasis, MMP-2 expression, angiogenesis, lymphangiogenesis, and low apoptotic index (AI). The patients whose tumors had strong VEGF-C expression and low AI underwent a poorer prognosis than did those with weak VEGF-C expression and high AI. Conclusion: VEGF-C expression is closely related to invasive phenotype and affects the patient's survival in ovarian carcinomas.
Relation:	EYE 19(5):571-574
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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