Association of tumour necrosis factor alpha-308 gene polymorphism with primary open-angle glaucoma in Chinese

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Title:	Association of tumour necrosis factor alpha-308 gene polymorphism with primary open-angle glaucoma in Chinese
Authors:	Lin, HJ;Tsai, FJ;Chen, WC;Shi, YR;Hsu, Y;Tsai, SW
Contributors:	附設醫院基因醫學部;China Med Coll Hosp, Dept Med Genet & Pediat, Taichung 404, Taiwan;China Med Coll Hosp, Dept Ophthalmol, Taichung 404, Taiwan;China Med Coll Hosp, Dept Occupat Safety & Hlth, Taichung 404, Taiwan;China Med Coll Hosp, Inst Environm Med, Taichung 404, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:46:04 (UTC+8)
Publisher:	NATURE PUBLISHING GROUP
Abstract:	Dihydrodiol dehydrogenase (DDH) is one of the major enzymes catabolizing polycyclic aromatic hydrocarbons in the liver. Although four DDH isoforms have been detected in the normal liver, only DDH1 and DDH2 have been detected in cancer cells of lung and esophagus. Moreover, the available information about hepatic pathophysiological regulation of DDH expression is limited. Therefore we addressed the question of DDH expression in patients with liver disorders, in particular, patients with hepatocellular carcinoma (HCC). Expression of DDH1/2 was determined by immunohistochemistry, immunoblotting and reverse transcription-polymerase chain reaction (RT-PCR) in 52 patients with resected HCC. DDH1/2 expression was detected in 31 (59.6%) of 52 pathological sections. Frequency of DDH1/2 expression was significantly higher in patients with tumor size >2 cm, and in those who had early local recurrence. In addition to the tumor size and frequency of local recurrence, our results further indicated that expression of DDH1/2 was correlated with those of cyclooxygenase 2 (COX-2), interleukin-6 (IL-6), microsomal epoxide hydrolase (mEpH) and Soluble epoxide hydrolase (sEpH) in HCC patients. Interestingly, the expression of DDH1/2 was found inversely correlated with that of glutathione S-transferase (GST) and NADPH p450 reductase (NPR). In conclusion, these results indicate that DDH expression was significantly decreased in about 40% of HCC patients. However, in the bordering nonneoplastic region of liver DDH1/2 expression increased, and the increased DDH1/2 expression correlated with tumor size and the disease progression.
Relation:	EYE 17(1):31-34
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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