Association of E-cadherin gene 3 '-UTR C/T polymorphism with calcium oxalate stone disease

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Title:	Association of E-cadherin gene 3 '-UTR C/T polymorphism with calcium oxalate stone disease
Authors:	Tsai, FJ;Wu, HC;Che, HY;Lu, HF;Hsu, CD;Chen, WC
Contributors:	附設醫院基因醫學部;China Med Coll Hosp, Dept Med Genet, Taichung, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung, Taiwan;China Med Coll Hosp, Dept Urol, Taichung, Taiwan;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung, Taiwan;Natl Tsing Hua Univ, Dept Life Sci, Hsinchu, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:45:52 (UTC+8)
Publisher:	KARGER
Abstract:	Aim: To evaluate whether positron emission tomography (PET) with F-18-2-deoxyglucose (FDG) can detect pelvic lymph node metastases in prostate cancer patients who had elevated serum prostate-specific antigen (PSA) levels after treatment. Methods: Twenty-four patients with a rising serum PSA level after treatment for localized prostate cancer were examined with FDG-PET before pelvic lymph node dissection. All patients had negative findings on whole body bone scan and equivocal pelvic computed tomography (CT) results. The results of FDG-PET were then compared to the histology of the pelvic lymph nodes obtained at surgery. Results: Lymph node metastases were detected by histopathological examination in 16/24 (66.7%) patients. At the sites with histopathologicaliy proven metastases, increased FDG uptake was found in 12/16 (75.0%) patients. In addition, there were 4 patients with false-negative results, but no patient with a false-positive result on FIDG-PET images. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FDG-PET in detecting metastatic pelvic lymph nodes were 75.0, 100.0, 83.3, 100.0, and 67.7%, respectively. Conclusions: These results suggest that FDG-PET may be a valuable diagnostic tool in the staging of pelvic lymph nodes in patients with PSA relapse after treatment of localized prostate cancer when the whole body bone scan is negative and pelvic CT findings are equivocal. Copyright (C) 2003 S. Karger AG, Basel.
Relation:	UROLOGIA INTERNATIONALIS 70(4):278-281
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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