Lack of association of interleukin-1 beta gene polymorphisms in Chinese patients with systemic lupus erythematosus

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29915

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题名:	Lack of association of interleukin-1 beta gene polymorphisms in Chinese patients with systemic lupus erythematosus
作者:	Huang, CM;Wu, MC;Wu, JY;Tsai, FJ
贡献者:	附設醫院基因醫學部;China Med Coll Hosp, Dept Med Genet, Taichung, Taiwan;China Med Coll Hosp, Dept Internal Med, Div Immunol & Rheumatol, Taichung, Taiwan
日期:	2002
上传时间:	2010-09-24 14:45:30 (UTC+8)
出版者:	SPRINGER-VERLAG
摘要:	The aim of this study was to investigate the relationships among technetium-99m tetrofosmin (Tc-TF) accumulation in parathyroid adenoma and the expression of P-glycoprotein (Pgp) or multidrug resistance related protein (MRP). Before operation, 33 patients with parathyroid adenomas (larger than 1.5 gm) were studied with parathyroid scintigraphy 10 minutes and 2 hours after intravenous injection of Tc-TF before operation. Immunohistochemical analyses (IHA) were performed on multiple nonconsecutive sections of operative parathyroid specimens to detect Pgp or MRP expression. According to the results of IHA, the 33 parathyroid adenomas were separated into four groups: (1) 2 adenomas with both positive Pgp and positive MRP expression, (2) 1 adenomas with positive Pgp but negative MRP expression. (3) 2 adenomas with negative Pgp but positive MRP expression, and (4) 28 adenomas with both negative Pgp and negative MRP expression. All of 28 adenomas in the group 4 could be detected by Tc-TF parathyroid imaging. All of 5 adenomas in the groups 1 to 3 could not be detected by TcTF parathyroid imaging (p < 0.05). Not only the size of parathymid adenomas, but also significant Pgp or MRP expression limited the sensitivity of Tc-TF parathyroid imaging to localize parathyroid adenomas before operation. (C) 2002 Elsevier Science Inc. All rights reserved.
關聯:	RHEUMATOLOGY INTERNATIONAL 21(5):173-175
显示于类别:	[台中附設醫院] 期刊論文

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