Distributions of p53 codon 72 polymorphism in primary open angle glaucoma

CMUR > China Medical University Hospital > Jurnal articles > Item 310903500/29911

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/29911

Title:	Distributions of p53 codon 72 polymorphism in primary open angle glaucoma
Authors:	Lin, HJ;Chen, WC;Tsai, FJ;Tsai, SW
Contributors:	附設醫院基因醫學部;China Med Coll Hosp, Dept Med Genet & Pediat, Taichung 404, Taiwan;China Med Coll, Dept Ophthalmol, Taichung, Taiwan;China Med Coll, Dept Occupat Safety & Hlth, Taichung, Taiwan;China Med Coll, Inst Environm Med, Taichung, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:45:24 (UTC+8)
Publisher:	BRITISH MED JOURNAL PUBL GROUP
Abstract:	Baicalin, baicalein, wogonoside and wogonin are bioactive flavone constituents of Scutellariae Radix with a wide range of beneficial activities. The purpose of this study attempted to compare the absorption of baicalin, baicalein, wogonoside and wogonin between traditional decoction and a commercial powder preparation of Scutellariae Radix. Eight healthy male volunteers received 90 mL traditional decoction (equivalent to 9 g crude drug) and 4.3 g commercial powder preparation (comparable to 9 g crude drug) of Scutellariae Radix in a randomized crossover design. The contents of baicalin, baicalein, wogonoside and wogonin in traditional decoction and commercial preparation as well as their metabolites in urine were determined by HPLC methods. The relative flavone bioavailability was obtained by comparing urinary recoveries of glucuronides/sulfates of wogonin and baicalein within 36 hr after dosing. The mean (+/- S.E.) cumulated renal excretion of glucuronides/sulfates of baicalein and wogonin after intake of traditional decoction were 66.0 +/- 8.7 mumol (4.0 +/- 0.5% of dose) and 30.8 +/- 8.2 mumol (7.1 +/- 1.8% of dose), whereas those for commercial preparation were 40.2 +/- 6.0 umol (2.2 +/- 0.3% of dose) and 14.7 +/- 3.7 mumol (4.1 +/- 1.0% of dose), respectively. The results indicated that the bioavailability of wogonin/wogonoside was about two times when compared to that of baicalein/baicalin from either traditional decoction or the commercial preparation. The flavone bioavailability from commercial preparation was significantly lower by 44.2 +/- 0.1 % for baicalin/baicalein and by 42.3 +/- 0.1 % for wogonoside/wogonin than those from traditional decoction.
Relation:	BRITISH JOURNAL OF OPHTHALMOLOGY 86(7):767-770
Appears in Collections:	[China Medical University Hospital] Jurnal articles

Files in This Item:

There are no files associated with this item.

Loading...