A novel nonsense mutation of the sedlin gene in a family with spondyloepiphyseal dysplasia tarda

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29907

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题名:	A novel nonsense mutation of the sedlin gene in a family with spondyloepiphyseal dysplasia tarda
作者:	Shi, YR;Lee, CC;Hsu, YA;Wang, CH;Tsai, FJ
贡献者:	附設醫院基因醫學部;China Med Coll Hosp, Dept Med Genet, Taichung 404, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung, Taiwan;China Med Coll Hosp, Dept Neurol, Taichung, Taiwan
日期:	2002
上传时间:	2010-09-24 14:45:20 (UTC+8)
出版者:	KARGER
摘要:	The authors investigated the relationship between respiratory effects and air pollutants among asthmatics in central Taiwan. A total of 12,926 subjects were selected from 8 junior high schools. Data about monthly hospital admissions for respiratory illnesses were collected over a period of 1 yr from the National Insurance Bureau. Data included how frequently subjects purchased medication and the respiratory symptoms recorded by clinic and hospital personnel. Pulmonary function tests were administered to 20% of the total study population, which was selected randomly. Data about monthly levels of air pollutants (i.e., particulate matter 10 mum and less [PM10], ozone [O-3], sulfur dioxide [SO2], and nitrogen dioxide [NO2]) were provided by Taiwan's Environmental Protection Agency. The prevalence rates of asthma were correlated significantly with NO2 (r = .63) and 03 (r = .51) concentrations. Levels of NO2 and PM10 were correlated significantly with monthly hospital admissions. Forced vital capacity, forced expiratory volume in 1 sec, and peak expiratory flow for asthmatics in central Taiwan were 6-11% lower than normal predicted values for the general Taiwanese student population, adjusted for age, height, and weight. In conclusion, the increased risk of asthma and the frequency of monthly hospital admissions among asthmatics may be correlated positively with pollution levels-especially NO2 and PM10.
關聯:	HUMAN HEREDITY 54(1):54-56
显示于类别:	[台中附設醫院] 期刊論文

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