(-)-Menthol Inhibits DNA Topoisomerases I, II α and β and Promotes NF-Î B expression in Human Gastric Cancer SNU-5 Cells

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 中醫學系暨碩博班 > 期刊論文 > Item 310903500/2989

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/2989

题名:	(-)-Menthol Inhibits DNA Topoisomerases I, II α and β and Promotes NF-Î B expression in Human Gastric Cancer SNU-5 Cells
作者:	林景彬(Jing-Pin Lin);(Hsu-Feng Lu);李昭宏(Jau-Hong Lee);林昭庚;夏德椿(Te-Chun Hsia);吳禮字;鍾景光(Jing-Gung Chung)*
贡献者:	中醫學院中醫學系學士班中醫方藥學科
关键词:	(-)-Menthol;DNA topoisomerase I;topoisomerase IIα;topoisomerase IIβ;gastric cancer
日期:	2005-05
上传时间:	2009-08-20 17:58:16 (UTC+8)
摘要:	It has been reported that (-)-Menthol can inhibit the growth of rat liver epithelial tumor cells and is a potent chemopreventive agent. The purpose of the present experiment was to examine and identify cellular processes leading to cell death which are affected by (-)-Menthol in human gastric SNU-5 cancer cells. Cell death (cytotoxicity) was examined and analyzed by trypan blue stain and flow cytometric methods. It was shown that (-)-Menthol inhibited the proliferation of the cells in a dose- and time-dependent manner, inhibited topoisomerase I, IIα and IIβ, but promoted the levels of NF-Î B gene expression based on the Western blot and polymerase chain reaction (PCR) and cDNA microarray methods. These data suggest that (-)-Menthol may induce cytotoxicity through inhibiting gene expression of topoisomerase I, IIα and IIβ and promoting the gene expression of NF-Î B in SNU-5 cells.
關聯:	ANTICANCER RESEARCH 25(3B):2069~2074
显示于类别:	[中醫學系暨碩博班] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
	0Kb	Unknown	427	检视/开启

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章