Tensile forces attenuate estrogen-stimulated collagen synthesis in the ACL

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Title:	Tensile forces attenuate estrogen-stimulated collagen synthesis in the ACL
Authors:	Lee, CY;Smith, CL;Zhang, XL;Hsu, HC;Wang, DY;Luo, ZP
Contributors:	附設醫院骨科部;Baylor Coll Med, Dept Orthopaed Surg, Houston, TX 77030 USA;China Med Univ & Hosp, Dept Orthopaed Surg, Taichung, Taiwan;Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA;Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
Date:	2004
Issue Date:	2010-09-24 14:44:51 (UTC+8)
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Abstract:	Probiotics are perceived to exert beneficial effects in the prevention and treatment of allergic diseases via modifying the gut ecosystem. The aim of this study was to assess whether ingestion of fermented milk containing Lactobacillus paracasei-33 (LP-33), a strain newly isolated from the human intestinal tract, can improve the quality of life of patients with perennial allergic rhinitis. In a randomized, double-blind, placebo-controlled trial, we gave patients fermented milk with (n = 60) or without (n = 20) the addition of LP-33 (2 x 109 colony-forming units per bottle) for 30 days. A modified questionnaire concerning pediatric rhinoconjunctivitis quality of life was administered to all subjects or their parents at each clinical visit. Scores for the overall quality of life significantly decreased in the LP-33 group as compared with the placebo group, in both frequency (-16.02 +/- 2.14 vs. -7.27 +/- 3.55, respectively; p = 0.037) and level of bother (-16.35 +/- 2.33 vs. -6.20 +/- 3.13, respectively; p = 0.022) after the 30-day treatment. Subjects reported no severe adverse effects such as fever, abdominal pain, or diarrhea. The results suggest that ingestion of LP-33-fortified fermented milk for 30 days can effectively and safely improve the quality of life of patients with allergic rhinitis, and may serve as an alternative treatment for allergic rhinitis.
Relation:	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 317(4):1221-1225
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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