Chondrosarcoma of the chest wall - A retrospective clinical analysis

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Title:	Chondrosarcoma of the chest wall - A retrospective clinical analysis
Authors:	Fong, YC;Pairolero, PC;Sim, FH;Cha, SS;Blanchard, CL;Scully, SP
Contributors:	附設醫院骨科部;Mayo Clin, Dept Orthoped Surg, Rochester, MN 55905 USA;Mayo Clin, Dept Biostat, Rochester, MN 55905 USA;China Med Univ Hosp, Dept Orthoped Surg, Taichung, Taiwan;Mayo Clin, Dept Surg, Rochester, MN 55905 USA
Date:	2004
Issue Date:	2010-09-24 14:44:49 (UTC+8)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Abstract:	Urokinase is thought to be involved in the formation of oral cancer, although there is a lack of genetic evidence. Our aim was to study single nucleotide polymorphisms in order to investigate the possibility. A total of 130 oral cancer patients and 105 controls were studied. Polymerase chain reaction (PCR) based restriction analysis was used to identify the C/T polymorphism of the urokinase gene, which is located on the 3'-untranslated region (3'-UTR) of chromosome 10. There was a significant difference in the distribution of the urokinase gene 3'-UTR C/T polymorphism frequency between cancer patients and the normal control group (P<0.05). The "T" allele was prominent in the cancer group. The odds ratio for the risk of the "T" allele in cancer patients was 2.71 (95% CI=1.325similar to5.562). The cancer patients were further categorized according to gender and whether or not they were habitual smokers or betel nut chewers. These clinical parameters were then compared with tumor cell differentiation and tumor progression. No significant differences were found. Therefore, the urokinase gene 3'-UTR "T" allele is associated with oral cancer and may play a role in oral cancer formation. However, we did not find the relationship between tumor progression and this polymorphism.
Relation:	CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (427):184-189
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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