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http://ir.cmu.edu.tw/ir/handle/310903500/29854
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| 題名: | Pallidotorny effect on the cortical excitability in patients with severe Parkinson's disease |
| 作者: | Tsai, CH;Chang, FC;Lu, CS;Lee, ST;Huang, YT;Lu, MK;Chen, RS;Wu, T;Lee, JD;Weng, YH;Chang, HC |
| 貢獻者: | 附設醫院神經部;China Med Univ Hosp, Dept Neurol, Neurosci Lab, Taichung 404, Taiwan;China Med Univ, Inst Med Sci, Taichung, Taiwan;Chang Gung Mem Hosp, Dept Neurol, Movement Disorders Unit, Taipei 10591, Taiwan;Chang Gung Mem Hosp, Dept Neurosurg, Taipei 10591, Taiwan;Chang Gung Mem Hosp, Dept Elect Engn, Taipei 10591, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:43:57 (UTC+8) |
| 出版者: | WILEY-LISS |
| 摘要: | Memory is one of the most fundamental mental processes, and various approaches have been used to understand the mechanisms underlying this process. Nitric oxide (NO), cGMP and protein kinase G (PKG) are involved in the modulation of synaptic plasticity in various brain regions. YC-1, which is a benzylindazole derivative, greatly potentiated the response of soluble guanylate cyclase to NO (up to several hundreds fold). We have previously shown that YC-1 markedly enhances long-term potentiation in hippocampal and amygdala slices via NO-cGMP-PKG-dependent pathway. We here further investigated whether YC-1 promotes learning behaviour in Morris water maze and avoidance tests. It was found that YC-1 shortened the escape latency in the task of water maze, increased and decreased the retention scores in passive and active avoidance task, respectively. Administration of YC-1 30 min after foot-shock stimulation did not significantly affect retention scores in response to passive avoidance test. Administration of scopolamine, a muscarinic antagonist, markedly impaired the memory acquisition. Pretreatment of YC-1 inhibited the scopolamine-induced learning deficit. The enhancement of learning behaviour by YC-1 was antagonized by intracerebroventricular injection of NOS inhibitor L-NAME and PKG inhibitors of KT5823 and Rp-8-Br-PET-cGMPS, indicating that NO-cGMP-PKG pathway is also involved in the learning enhancement action of YC-1. YC-1 is thus a good drug candidate for the improvement of learning and memory. |
| 關聯: | MOVEMENT DISORDERS 20(4):463-470 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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