Focal hand myoclonus caused by a small hematoma underneath the cerebral motor cortex

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Title:	Focal hand myoclonus caused by a small hematoma underneath the cerebral motor cortex
Authors:	Tsai, PC;Chang, FC;Tsai, CH;Jang, FR;Shen, AN;Huang, YT;Lai, SC;Yeh, TH;Lu, MK;Lu, CS
Contributors:	附設醫院神經部;China Med Coll Hosp, Dept Neurol, Neurosci Lab, Taichung 404, Taiwan;Chang Gung Mem Hosp, Dept Neurol, Movement Disorders Unit, Taipei 10591, Taiwan;Chang Gung Mem Hosp, Dept Neurol, Neurosci Lab, Taipei 10591, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:43:43 (UTC+8)
Publisher:	KARGER
Abstract:	A polymorphism in the cystatin C (CST3) gene was suggested to associate with Alzheimer's disease (AD). In the present study we attempted to determine the association between CST3 polymorphism and AD or vascular dementia (VD), and whether such effects are dependent of the APOE4 allele. The polymorphisms of CST3 genotype were determined using polymerase chain reactions (PCR) followed by gel electrophoresis in 124 AD, 70 VD, and 115 control individuals. No statistical difference in CST3B allele frequencies was observed among all three groups. Associations between CST3B/B genotype and AD patients older than 75-year-old, or VD patients younger than 75-year-old were evident. The APOE4 allele alone significantly increased the odds for the developing AD, but not VD. A logistic regression analysis revealed that either CST3 or its interaction with APOE4 were not significant predictors of AD. However, a synergistic association of CST3 and APOE4 alleles was observed in predicting VD patients. These results suggest that CST3 might interact with APOE4 on conferring vascular pathologies.
Relation:	EUROPEAN NEUROLOGY 50(2):114-117
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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