ATP7A gene mutations in 16 patients with Menkes disease and a patient with occipital horn syndrome

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Title:	ATP7A gene mutations in 16 patients with Menkes disease and a patient with occipital horn syndrome
Authors:	Gu, YH;Kodama, H;Murata, Y;Mochizuki, D;Yanagawa, Y;Ushijima, H;Shiba, T;Lee, CC
Contributors:	附設醫院神經部;Teikyo Univ, Sch Med, Dept Pediat, Itabashi Ku, Tokyo 1738605, Japan;Univ Tokyo, Grad Sch Med, Sch Int Hlth, Dept Dev Med Sci, Tokyo, Japan;Kitasato Univ, Sch Med, Sagamihara, Kanagawa 228, Japan;China Med Coll Hosp, Dept Neurol, Taichung, Taiwan
Date:	2001
Issue Date:	2010-09-24 14:43:37 (UTC+8)
Publisher:	WILEY-LISS
Abstract:	Background Intrahepatic arterial injection of Y-90 glass microspheres (Y-90 microspheres) is a useful therapeutic modality for inoperative liver tumour. Recently, a new concept of interstitial radiotherapy in the treatment of hepatic malignancies has been carried out with even more encouraging results. However, information regarding this technique is still very rare. The purpose of this study was to analyse the kinetics and biodistribution of Y-90 microspheres in rats with hepatic tumours following intra-tumoural injection. Methods Twenty male Sprague-Dawley rats with hepatoma were killed at 1 h, 24 h, 48 h and 72 h (five rats each time) after intra-tumoural injection of approximately 7.4 MBq of Y-90 microspheres. Samples of various organs were obtained and used to calculate the tissue concentrations and radiation doses. Results Our data showed that the radioactivity in the tumour was very high throughout this study. The lung was the only organ other than the tumour which showed high radioactivity. The concentrations of radioactivity in other organs, such as normal liver, muscle, spleen, bone, testis, and whole blood were quite low throughout the study. Conclusion Direct intra-tumoural injection of Y-90 microspheres is extremely attractive as a clinical therapeutic alternative in hepatoma patients. ( (C) 2001 Lippincott Williams & Wilkins).
Relation:	AMERICAN JOURNAL OF MEDICAL GENETICS 99(3):217-222
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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