PUNICALAGIN-INDUCED RELEASE OF NOREPINEPHRINE REVERSES ORTHOSTATIC HYPOTENSION IN RATS

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Title:	PUNICALAGIN-INDUCED RELEASE OF NOREPINEPHRINE REVERSES ORTHOSTATIC HYPOTENSION IN RATS
Authors:	CHANG, TK;HSU, FL;CHENG, JT
Contributors:	附設醫院神經部;NATL CHENG KUNG UNIV,COLL MED,DEPT PHARMACOL,TAINAN 70101,TAIWAN;CHINA MED COLL HOSP,DEPT NEUROL,TAICHUNG 40408,TAIWAN;TAIPEI MED COLL,DEPT PHARMACEUT SCI,TAIPEI 10502,TAIWAN
Date:	1994
Issue Date:	2010-09-24 14:43:23 (UTC+8)
Publisher:	JOHN WILEY & SONS LTD
Abstract:	A series of 3',6,7-substituted 2-phenyl-4-quinolones were designed and synthesized as antimitotic antitumor agents. All compounds showed cytotoxic effects (log GI(50) less than or equal to -4.0; log drug molar concentration required to cause 50% inhibition) against the growth of a variety of human tumor cell lines, including those derived from solid tumors such as non-small cell lung, colon, central nervous system, ovary, prostate, and breast cancers, when evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. The most potent compound (26) demonstrated strong cytotoxic effects with GI(50) values in the nanomolar or subnanomolar range in almost all the tumor cell lines. Compound 26 was also a potent inhibitor of tubulin polymerization and radiolabeled colchicine binding to tubulin, with activity comparable to those of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4.
Relation:	PHYTOTHERAPY RESEARCH 8(6):348-351
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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