OVERLAPPING SYNDROME OF MERRF AND MELAS - MOLECULAR AND NEURORADIOLOGICAL STUDIES

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Title:	OVERLAPPING SYNDROME OF MERRF AND MELAS - MOLECULAR AND NEURORADIOLOGICAL STUDIES
Authors:	CHEN, RS;HUANG, CC;LEE, CC;WAI, YY;HSI, MS;PANG, CY;WEI, YH
Contributors:	附設醫院神經部;CHANG GUNG MEM HOSP,DEPT NEUROL,199 TUNG HWA N RD,TAIPEI,TAIWAN;CHANG GUNG MEM HOSP,DEPT RADIOL,TAIPEI,TAIWAN;CHINA MED COLL HOSP,DEPT NEUROL,TAIPEI,TAIWAN;NATL YANG MING MED COLL,DEPT BIOCHEM,TAIPEI,TAIWAN
Date:	1993
Issue Date:	2010-09-24 14:43:17 (UTC+8)
Publisher:	MUNKSGAARD INT PUBL LTD
Abstract:	The effects of 6-hydroxydopamine (6-OHDA) on carbon tetrachloride (CCl4)-induced acute liver injury were examined in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Plasma glutamate-pyruvate transaminase (GPT) activity was increased in both strains after one dose of CCl4 administration, although the increase was more significant in SHR than in WKY. Pretreatment with 6-OHDA inhibited the increase in GPT activity after CCl4 administration in both strains and especially in SHR. 6-OHDA also reduced the noradrenaline (NA) content of the liver and increased the hepatic blood flow in both strains. It caused a greater decrease in blood pressure in SHR than in WKY. The results suggest that 6-OHDA blocks the sympathetic neural activity in the liver, resulting in vasodilatation and increase in hepatic blood flow and thereby alleviating the circulatory disturbance produced by CCl4 preventing acute liver damage, especially in SHR.
Relation:	ACTA NEUROLOGICA SCANDINAVICA 87(6):494-498
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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