Application of neuronavigator coupled with an operative microscope and electrocorticography in epilepsy surgery

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Title:	Application of neuronavigator coupled with an operative microscope and electrocorticography in epilepsy surgery
Authors:	Cho, DY;Lee, WY;Lee, HC;Chen, CC;Tso, ML
Contributors:	附設醫院神經外科;China Med Univ Hosp, Dept Neurosurg, Taichung 404, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:43:01 (UTC+8)
Publisher:	ELSEVIER SCIENCE INC
Abstract:	This study was designed to determine the effects of 17 beta-estradiol (E-2) in overcoming the cardiac over-loading and cardiac fibrosis in rats. E-2 (100 ng/kg) or oil was applied in female Sprague-Dawley rats with or without bilateral ovariectomy and with or without coaretation of the abdominal aorta after 4 or 8 days. By post-operative day 4, the heart weight, the left ventricular weight, the latent form of MMP-2 in rat hearts with or without the ovary intact had significantly increased while these changes were reversed after E2 treatment. Although animals with the ovaries intact overcame the hypertrophic effects and the consumption of MMP-2, these effects were not restored in ovariectornized animals in which more fibrosis could be found by day 8. Among the IGF-I signaling, the levels of IGF-I, the activities of PI3K-Akt for cardiomyocyte survival, and MEK-ERKs for non-cardiomyocyte proliferation pathways had significantly increased by day 4. These increasing trends were enhanced by E-2 treatment. However, down-regulation was only observed on day 8 in ovariectornized animals. Similarly, elevated expressions of the steady-state mRNA of IGF-I, IGF-IR, and Cox vb were observed on day 4 in animals with the ovaries intact and these expressions were enhanced by E2 treatment. In contrast, down-regulation on day 8 in ovariectomized animals was not enhanced by E-2. The calcineurin/NFAT-3 pathway was suppressed on day 4 but was elevated on day 8 in ovariectornized animals. These findings indicate that signaling pathways may be plausible mechanisms for the cardiac protective effects of E-2 administration. (c) 2005 Elsevier Inc. All rights reserved.
Relation:	SURGICAL NEUROLOGY 64(5):411-418
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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