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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29807
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| 題名: | A stainless steel sheath for endoscopic surgery and its application in surgical evacuation of putaminal haemorrhage |
| 作者: | Chen, CC;Cho, DY;Chang, CS;Chen, JT;Lee, WY;Lee, HC |
| 貢獻者: | 附設醫院神經外科;China Med Univ Hosp, Dept Neurosurg, Taichung 404, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:42:58 (UTC+8) |
| 出版者: | CHURCHILL LIVINGSTONE |
| 摘要: | Isoflavone supplements are nowadays widely used as alternative for hormone replacement therapy. However, the safety remains unanswered. This study attempted to investigate the effect of Pueraria lobata root decoction (PLRD), an isoflavone-rich herb, on the pharmacokinetics of methotrexate (MTX), a bicarboxylate antimetabolite with narrow therapeutic window. Rats were orally and intravenously given methotrexate alone and coadministered with PLRD. Blood samples were withdrawn via cardiopuncture at specific time points after drug administration. Serum methotrexate concentrations were assayed by specific monoclonal fluorescence polarization immunoassay method. Pharmacokinetic parameters were calculated using noncompartment model of WINNONLIN for both oral and intravenous data of MTX. Our results showed that coadministration of 4.0 g/kg and 2.0 g/kg of PLRD significantly increased the AUC(0-t) by 207.8% and 127.9%, prolonged the mean residence time (MRT) by 237.8 and 155.2%, respectively, finally resulted in surprisingly high mortalities of 57.1% and 14.3% in rats. When MTX was given intravenously, the coadministration of PLRD at 4.0 g/kg significantly increased the half-life by 53.9% and decreased the clearance by 47.9%. In conclusion, the coadministration of PLRD significantly decreased the elimination and resulted in markedly increased exposure of MTX in rats. (c) 2005 Elsevier Inc. All rights reserved. |
| 關聯: | JOURNAL OF CLINICAL NEUROSCIENCE 12(8):937-940 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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