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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29779
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| 題名: | Quantitative structure-activity relationships for the pre-steady-state inhibition of cholesterol esterase by 4-nitrophenyl-N-substituted carbamates |
| 作者: | Lin, G;Liao, WC;Chiou, SY |
| 貢獻者: | 附設醫院神經外科;Natl Chung Hsing Univ, Dept Chem, Taichung 40227, Taiwan;Natl Chung Hsing Univ, Inst Biochem, Taichung 40227, Taiwan;China Med Coll Hosp, Dept Neurosurg, Taichung, Taiwan |
| 日期: | 2000 |
| 上傳時間: | 2010-09-24 14:42:26 (UTC+8) |
| 出版者: | PERGAMON-ELSEVIER SCIENCE LTD |
| 摘要: | Backgrounds/Aims: Combination IFN-EI and ribavirin therapy for hepatitis C virus-infected patients has been reported to improve the response rate up to 50%, In this study, we aimed to study further the role of ribavirin in hepatitis C virus-specific immune responses. Methods: We immunized mice with hepatitis C virus core protein with or without different concentrations of ribavirin, Forty days after immunization, hepatitis C virus-specific immune responses were followed in these mice. Results: We found that the mice immunized with core antigen once every 2 weeks and 0.5 mg ribavirin every day showed higher levels of core-specific IgG2 compared with those mice immunized with core antigen only. In addition, core antigen-stimulated spleen cells produced higher levels of T helper type 1 cytokines and the core-specific cytotoxic T cell activity also increased significantly. Furthermore, lipopolysaccharide-stimulated peritoneal cells produced higher levels of IL-12 in ribavirin-treated mice, and peritoneal cells isolated from naive mice also produced significantly higher level of IL-12 when cultured with ribavirin. Conclusions: Ribavirin may significantly promote the T helper type 1 immune response in vivo and, furthermore, the effect of ribavirin on IL-12 level produced by accessory cells may contribute to the T helper type 1 enhancing effect. |
| 關聯: | BIOORGANIC & MEDICINAL CHEMISTRY 8(11):2601-2607 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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