Prognostic value of multidrug resistance 1, glutathione-S-transferase-pi and p53 in advanced nasopharyngeal carcinoma treated with systemic chemotherapy

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Title:	Prognostic value of multidrug resistance 1, glutathione-S-transferase-pi and p53 in advanced nasopharyngeal carcinoma treated with systemic chemotherapy
Authors:	Hsu, CH;Chen, CL;Hong, RL;Chen, KL;Lin, JF;Cheng, AL
Contributors:	附設醫院病理部;Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 10002, Taiwan;Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan;Natl Taiwan Univ Hosp, Dept Pathol, Taipei 100, Taiwan;China Med Coll Hosp, Dept Pathol, Taichung, Taiwan;Natl Taiwan Univ, Coll Med, Ctr Canc Res, Taipei 10018, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:42:15 (UTC+8)
Publisher:	KARGER
Abstract:	Background. Post-operative nausea and vomiting is a common complication following general anaesthesia. Traditional Chinese medicine indicates that acupressure therapy may reduce nausea and vomiting in certain ailments. Aim(s) of the study. The aim of this study was to examine the effect of stimulating two acupressure points on prevention of post-operative nausea and vomiting. Design and methods. A randomized block experimental design was used. The Rhodes Index of Nausea, Vomiting and Retching (INVR) questionnaire was used as a tool to measure incidence. To control the motion sickness variable, the subjects who underwent functional endoscopic sinus surgery (FESS) under general anaesthesia were randomly assigned to a finger-pressing group, a wrist-band group, and a control group. There were 150 subjects in total with each group consisting of 50 subjects. The acupoints and treatment times were similar in the finger-pressing group and wrist-band pressing group, whereas only conversation was employed in the control group. Results. Significant differences in the incidence of the post-operative nausea and vomiting were found between the acupressure, wrist-band, and control groups, with a reduction in the incidence rate of nausea from 73.0% to 43.2% and vomiting incidence rate from 90.5% to 42.9% in the former. The amount of vomitus and the degree of discomfort were, respectively, less and lower in the former group. Conclusion. In view of the total absence of side-effects in acupressure, its application is worthy of use. This study confirmed the effectiveness of acupressure in preventing post-operative nausea and vomiting.
Relation:	ONCOLOGY 62(4):305-312
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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