Expression of multidrug resistance 1 and glutathione-S-transferase-pi protein in nasopharyngeal carcinoma

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29766

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题名:	Expression of multidrug resistance 1 and glutathione-S-transferase-pi protein in nasopharyngeal carcinoma
作者:	Chen, CL;Sheen, TS;Lou, IU;Huang, AC
贡献者:	附設醫院病理部;China Med Coll Hosp, Dept Pathol, Taichung 404, Taiwan;Natl Taiwan Univ, Coll Med, Dept Pathol, Taipei, Taiwan;Natl Taiwan Univ, Coll Med, Dept Otolaryngol, Taipei, Taiwan
日期:	2001
上传时间:	2010-09-24 14:42:11 (UTC+8)
出版者:	W B SAUNDERS CO
摘要:	Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum. The study investigated the effects and mechanisms of aloe-emodin-induced cell death in human lung squamous cell carcinoma cell line CH27. Aloe-emodin (40 muM)-induced CH27 cell apoptosis was confirmed by DNA fragmentation (DNA ladders and sub-G(1) formation). Aloe-emodin-induced apoptosis of CH27 cells involved modulation of the expression of Bcl-2 family proteins, such as BclX(L), Bag-1, and Bak, and was associated with the translocation of Bak and Bax from cytosolic to particulate fractions. Aloe-emodin-treated CH27 cells had an increased relative abundance of cytochrome c in the cytosolic fraction. Results demonstrated that the activation of caspase-3, caspase-8, and caspase-9 is an important determinant of apoptotic death induced by aloe-emodin. These results suggest that aloe-emodin induces CH27 cell death by the Bax and Fas death pathway. (C) 2001 Elsevier Science B.V. All rights reserved.
關聯:	HUMAN PATHOLOGY 32(11):1240-1244
显示于类别:	[台中附設醫院] 期刊論文

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