Expression of Epstein-Barr virus in patients with Hodgkin's disease in Taiwan

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Title:	Expression of Epstein-Barr virus in patients with Hodgkin's disease in Taiwan
Authors:	Liu, SM;Chow, KC;Chiu, CF;Tzeng, CH
Contributors:	附設醫院病理部;China Med Coll Hosp, Dept Pathol, Taichung, Taiwan;Vet Gen Hosp Taipei, Dept Pathol, Taipei, Taiwan;Vet Gen Hosp Taipei, Ctr Canc, Taipei, Taiwan;China Med Coll Hosp, Div Hematol Oncol, Taichung, Taiwan;Vet Gen Hosp Taipei, Div Hematol Oncol, Taipei, Taiwan
Date:	1998
Issue Date:	2010-09-24 14:42:06 (UTC+8)
Publisher:	WILEY-LISS
Abstract:	The antioxidant properties of butein, isolated from Dalbergia odorifera T. Chen, were investigated in this study. Butein inhibited iron-induced lipid peroxidation in rat brain homogenate in a concentration-dependent manner with an IC50, 3.3 +/- 0.4 mu M. It was as potent as alpha-tocopherol in reducing the stable free radical diphenyl-2-picrylhydrazyl (DPPH) with an IC0.200, 9 2 +/- 1.8 mu M. It also inhibited the activity of xanthine oxidase with an IC50, 5.9 +/- 0.3 mu M. Besides, butein scavenged the peroxyl radical derived from 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH) in aqueous phase, but not that from 2,2-azobis(2,4-dimethylvaleronitrile) (AMVN) in hexane. Furthermore, butein inhibited copper-catalyzed oxidation of human low-density lipoprotein (LDL), as measured by conjugated dienes and thiobarbituric acid-reactive substance (TBARS) formations, and electrophoretic mobility in a concentration-dependent manner. Spectral analysis revealed that butein was a chelator of ferrous and copper ions. It is proposed that butein serves as a powerful antioxidant against lipid and LDL peroxidation by its versatile free radical scavenging actions and metal ion chelation. (C) 1998 Elsevier Science B.V.
Relation:	CANCER 83(2):367-371
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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