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| 題名: | Expression of Epstein-Barr virus in patients with Hodgkin's disease in Taiwan |
| 作者: | Liu, SM;Chow, KC;Chiu, CF;Tzeng, CH |
| 貢獻者: | 附設醫院病理部;China Med Coll Hosp, Dept Pathol, Taichung, Taiwan;Vet Gen Hosp Taipei, Dept Pathol, Taipei, Taiwan;Vet Gen Hosp Taipei, Ctr Canc, Taipei, Taiwan;China Med Coll Hosp, Div Hematol Oncol, Taichung, Taiwan;Vet Gen Hosp Taipei, Div Hematol Oncol, Taipei, Taiwan |
| 日期: | 1998 |
| 上傳時間: | 2010-09-24 14:42:05 (UTC+8) |
| 出版者: | WILEY-LISS |
| 摘要: | The antioxidant properties of butein, isolated from Dalbergia odorifera T. Chen, were investigated in this study. Butein inhibited iron-induced lipid peroxidation in rat brain homogenate in a concentration-dependent manner with an IC50, 3.3 +/- 0.4 mu M. It was as potent as alpha-tocopherol in reducing the stable free radical diphenyl-2-picrylhydrazyl (DPPH) with an IC0.200, 9 2 +/- 1.8 mu M. It also inhibited the activity of xanthine oxidase with an IC50, 5.9 +/- 0.3 mu M. Besides, butein scavenged the peroxyl radical derived from 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH) in aqueous phase, but not that from 2,2-azobis(2,4-dimethylvaleronitrile) (AMVN) in hexane. Furthermore, butein inhibited copper-catalyzed oxidation of human low-density lipoprotein (LDL), as measured by conjugated dienes and thiobarbituric acid-reactive substance (TBARS) formations, and electrophoretic mobility in a concentration-dependent manner. Spectral analysis revealed that butein was a chelator of ferrous and copper ions. It is proposed that butein serves as a powerful antioxidant against lipid and LDL peroxidation by its versatile free radical scavenging actions and metal ion chelation. (C) 1998 Elsevier Science B.V. |
| 關聯: | CANCER 83(2):367-371 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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