Utility of FDG-PET for investigating unexplained serum AFP elevation in patients with suspected hepatocellular carcinoma recurrence

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Title:	Utility of FDG-PET for investigating unexplained serum AFP elevation in patients with suspected hepatocellular carcinoma recurrence
Authors:	Chen, YK;Hsieh, DS;Liao, CS;Bai, CH;Su, CT;Shen, YY;Hsieh, JF;Liao, AC;Kao, CH
Contributors:	附設醫院核子醫學部;China Med Univ Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Univ Hosp, PET Ctr, Taichung 404, Taiwan;Shin Kong Wu HoSu Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Shin Kong Wu HoSu Mem Hosp, PET Ctr, Taipei, Taiwan;China Med Univ, Taichung, Taiwan;Natl Def Univ, Natl Def Med Ctr, TriServ Gen Hosp, Grad Inst Med Sci, Taipei, Taiwan;Natl Def Univ, Natl Def Med Ctr, TriServ Gen Hosp, Dept Surg, Taipei, Taiwan;Shin Kong Wu HoSu Mem Hosp, Dept Internal Med, Taipei, Taiwan;Shin Kong Wu HoSu Mem Hosp, Cent Lab, Dept Principal Investigator, Taipei, Taiwan;Shin Kong Wu HoSu Mem Hosp, Cent Lab, Dept Med Imaging, Taipei, Taiwan;ChiMei Med Ctr, Nucl Med Sect, Dept Radiol, Tainan, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:41:53 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	Application of neuronavigator coupled with an operative microscope and electrocorticography (ECoG) is a new trial for epilepsy surgery for achieving better seizure outcome and better efficiency for lesionectomy. We used a neuronavigator coupled with a microscope to delineate the magnetic resonance image-detected lesion for lesionectomy and used ECoG for evaluation of the epileptogenic foci. There were 46 patients with medically intractable partial seizures who underwent craniotomy for epilepsy surgery. Half of the patients had lesions at the temporal lobe and another half at the extratemporal lobe. Sixty-one percent of the patients were seizure-free (grade I) and 22% were nearly seizure-free (grade 11). Overall, 83% of the patients had satisfactory seizure control. Complete lesion removal was successful in 37 patients (80%). For lesions with requiring complete removal, neuronavigator coupled with a microscope was 95% effective for lesionectomy. Class A of postresection ECoG had a higher rate of seizure-free outcome (92%) (P <.05). On the other hand, 93% of patients (26/28) with seizure-free outcome (grade I) needed complete lesion resection (P <.05). Lesions at the extratemporal lobe yielded a higher rate of seizure-free outcome (78.2%, 18/23) (P <.05). Application of neuronavigator and ECoG (additional cortical resection) is usually necessary for temporal lobe lesions. All patients with cavernous hemangioma were seizure-free. The complication rate in our study was 8.7%. Neuronavigator coupled with a microscope provides efficacy and safety to complete lesionectomy, which is a key point of seizure outcome. Intraoperative ECoG is valuable for evaluating the epileptogenic foci for epilepsy surgery especially for lesions at the temporal lobe. (c) 2005 Elsevier Inc. All rights reserved.
Relation:	ANTICANCER RESEARCH 25(6C):4719-4725
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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